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Clinical dimensions of people with co-occurring obsessive-compulsive and related disorders and multiple sclerosis: a scoping review protocol.
BMJ Open
May 2024
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Introduction: Multiple sclerosis (MS) is an immune-mediated demyelinating disease with a significant burden of neuropsychiatric sequelae. These symptoms, including depression and anxiety, are predictors of morbidity and mortality in people with MS. Despite a high prevalence of obsessive-compulsive disorder in MS, potentially shared pathophysiological mechanisms and overlap in possible treatments, no review has specifically examined the clinical dimensions of people with obsessive-compulsive and related disorders (OCRD) and MS.
View Article and Find Full Text PDFSoil greenhouse gas flux and nitrogen mineralization following manure application from tannin-fed dairy cows.
J Environ Qual
January 2024
Nelson Institute for Environmental Studies, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Growing concerns about environmental impacts of dairy farms have driven producers to address greenhouse gas (GHG) emissions and nitrogen (N) losses from soil following land application of dairy manure. Tannin dietary additives have proved to be a successful intervention for mitigating GHG and ammonia (NH ) emissions at the barn scale. However, it is unknown how land application of dairy manure from cows fed tannin diets affects crop-soil nitrogen dynamics and soil GHG flux.
View Article and Find Full Text PDFUse of Optical Genome Mapping to Detect Structural Variants in Neuroblastoma.
Cancers (Basel)
October 2023
Wolfson Childhood Cancer Research Centre, Translational & Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Background: Neuroblastoma is the most common extracranial solid tumour in children, accounting for 15% of paediatric cancer deaths. Multiple genetic abnormalities have been identified as prognostically significant in neuroblastoma patients. Optical genome mapping (OGM) is a novel cytogenetic technique used to detect structural variants, which has not previously been tested in neuroblastoma.
View Article and Find Full Text PDFConsumer-Led Investigation into Potential Issues That Arise When Testing Dairy Matrixes for Gluten With the NIMA Sensor.
J AOAC Int
November 2023
In Johnna's Kitchen, 1306 Barford Dr, Liberty, MO 64068, United States.
Background: Some consumers with celiac disease use personal, point-of-use gluten detection devices to test food. False-positive results may occur due to sampling, matrix effects, and sensor issues.
Objective: The purpose of the present study was to determine if the positive gluten results some users were obtaining when testing cream cheese and materials of similar consistency were false positives and, if so, what might be causing them to occur.
Assessment of Natural Language Processing Methods for Ascertaining the Expanded Disability Status Scale Score From the Electronic Health Records of Patients With Multiple Sclerosis: Algorithm Development and Validation Study.
JMIR Med Inform
January 2022
Data Science and Advanced Analytics, Unity Health Toronto, Toronto, ON, Canada.
Background: The Expanded Disability Status Scale (EDSS) score is a widely used measure to monitor disability progression in people with multiple sclerosis (MS). However, extracting and deriving the EDSS score from unstructured electronic health records can be time-consuming.
Objective: We aimed to compare rule-based and deep learning natural language processing algorithms for detecting and predicting the total EDSS score and EDSS functional system subscores from the electronic health records of patients with MS.
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