Author examines the reasons which in this century radically changed the epidemiological picture of tuberculosis in Italy as well as in other countries. Today the mortality and morbidity percentages are clearly lower than percentages pertinent to other pulmonary diseases, such COLD or lung cancer. Yet antitubercular struggle is not concluded: the chronic cases are still an important medical and social problem and Italian tuberculin indexes are not quite satisfactory. We can say that many battles are been won, but now war need be won, political reasons permitting.
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Eur J Pediatr
January 2025
Infectious Diseases Unit, Department of Health Sciences, Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.
Purpose: High-accuracy diagnostic screening tests for Mycobacterium tuberculosis (MTB) infection are required, primarily to detect patients with latent infections (LTBIs) in order to avoid their progression to active tuberculosis disease. The performance of the novel IGRA LIOFeron®TB/LTBI was evaluated in children. The originality of this test is the new MTB antigen contained (L-alanine dehydrogenase), identified as a tool to differentiate active TB from LTBI infection.
View Article and Find Full Text PDFIJTLD Open
January 2025
International Union Against Tuberculosis and Lung Disease, Paris, France.
One year on from the launch of our new open access (OA) journal, IJTLD OPEN, we review its impact. Similar to our flagship journal, the IJTLD, articles published in IJTLD OPEN span a range of topics related to lung health and the majority focus on TB in low- to middle-income countries (LMICs). Interestingly, there has been no lag period in readers accessing the content, with downloads for IJTLD OPEN soon matching and exceeding those for the IJTLD.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Respiratory infections, including tuberculosis, constitute a major global health challenge. Tuberculosis (TB), caused by (Mtb), remains one of the leading causes of mortality worldwide. The disease's complexity is attributed to Mtb's capacity to persist in latent states, evade host immune defenses, and develop resistance to antimicrobial treatments, posing significant challenges for diagnosis and therapy.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Department of International Public Health, Emergency Obstetric and Quality of Care Unit, Liverpool School of Tropical Medicine, Pembrooke Place, L3, 5QA, Liverpool, UK.
Background: The blended learning (BL) approach to training health care professionals is increasingly adopted in many countries because of high costs and disruption to service delivery in the light of severe human resource shortage in low resource settings. The Covid-19 pandemic increased the urgency to identify alternatives to traditional face-to-face (f2f) education approach. A four-day f2f antenatal care (ANC) and postnatal care (PNC) continuous professional development course (CPD) was repackaged into a 3-part BL course; (1) self-directed learning (16 h) (2) facilitated virtual sessions (2.
View Article and Find Full Text PDFCurr Pediatr Rev
January 2025
Department of Health Sciences, University of Florence, Florence, Italy.
Introduction: The diagnosis of pediatric tuberculosis (TB) is challenging, due to the lower sensitivity of microbiological tests, such as culture and microscopy, compared to their performance in adult cases. Guidelines have introduced molecular tests, including GeneXpert MTB/ RIF and GeneXpert MTB/RIF Ultra. These tests use a real-time polymerase chain reaction method and provide information on M.
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