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Vegetative Pyoderma Gangrenosum Mimicking Squamous Cell Carcinoma: A Poorly Recognized Diagnostic Challenge.
Am J Dermatopathol
December 2024
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI.
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis that is difficult to diagnose due to non-specific clinical, laboratory, and histopathologic features. Distinguishing pseudoepitheliomatous hyperplasia (PEH) from squamous cell carcinoma (SCC) is also histopathologically challenging. The connection between PEH and PG is not well recognized, and instances of PG mimicking SCC are rare.
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- * Early detection of multiple KAs is important for diagnosing underlying causes and preventing related health issues, which can improve patient quality of life and provide family counseling.
- * Current research is limited and often based on small studies, so this work aims to review existing knowledge on multiple KAs, especially linked to genetic syndromes, and to propose a diagnostic algorithm for better clinical guidance.
A Case Report of a Keratoacanthoma of the Lip in a Pediatric Patient and Narrative Review.
Ear Nose Throat J
October 2024
Department of Stomatology, New Century Women's and Children's Hospital, Qingdao, Shandong, China.
Keratoacanthoma (KA) is a self-regressing cutaneous tumor sharing clinical and histopathological similarities with squamous cell carcinoma. It is relatively uncommon and presents diagnostic challenges, particularly in pediatric patients. This paper presents a case study of KA affecting the upper lip keratosis in a 6-year-old girl.
View Article and Find Full Text PDFMULTIPLE KERATINOCYTIC CANCERS AFTER INTAKE OF ANTIHYPERTENSIVES (LISINOPRIL/BISOPROLOL/HCT) AND ANTIARRHYTMICS (PROPAFENONE): THE IMPORTANT NEW LINKS TO THE NITROSO-CONTAMINATION AND THE METABOLIC REPROGRAMMING OF THE FUTURE CANCER CELL.
Georgian Med News
June 2024
3Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria.
Article Synopsis
- The mechanisms behind the development of skin tumors are still not fully understood, particularly regarding the roles of photosensitivity and phototoxicity.
- Recent studies have linked specific nitrosamines, contaminants in common pharmaceuticals, to gene and phototoxicity in humans, raising concerns about their potential carcinogenic effects.
- Long-term use of contaminated medications may contribute to skin cancer risk by interfering with tumor suppressor genes and activating oncogenes, affecting overall cancer development.
Generalized Eruptive Keratoacanthoma (GEKA) after Pfizer mRNABNT162b2 (Comirnaty) COVID-19 Vaccination Successfully Treated with Cemiplimab.
Viruses
August 2024
Dermatology Unit "Daniele Innocenzi", "A. Fiorini" Hospital, via Firenze, 1, 04019 Terracina, Italy.
Article Synopsis
- * A 64-year-old man with a history of hypertension and diabetes developed multiple keratoacanthomas two weeks after his second booster dose, prompting diagnosis through physical and histopathological examinations.
- * The patient's condition improved significantly with treatment using cemiplimab, suggesting a possible immune-mediated reaction from the vaccine, but further studies are necessary to assess treatment safety and effectiveness.
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