AI Article Synopsis
- The study measured the reduction rates of various azo dyes using rat liver enzymes, finding amaranth and azosulfamide had the highest rates.
- Azo dyes were ranked based on the amount of arylamine produced per minute, with amaranth at 33.2 nmol and Sudan I at 1.03 nmol.
- The results indicated that water-soluble azo dyes were reduced more quickly than lipid-soluble ones, and dyes with electron-withdrawing groups on their aromatic rings also showed higher reduction rates.
Article Abstract
The rate of reduction was determined for a variety of azo dyes using the rat hepatic azoreductase enzyme system. In decreasing order, the rates of reduction for the azo dyes expressed as nmol of arylamine product formed/min/0.25 g of liver were amaranth (33.2), azosulfamide (32.5), orange G (12.4), 1,2-dimethyl-4-p-(carboxyphenylazo)-5-hydroxybenzene (CPA) (9.27), brilliant crystal scarlet (8.00), sulfachrysoidine (7.27), and Sudan I (1.03). A comparison of the partition coefficient with its rate of reduction indicated that the water-soluble azo dyes were reduced more rapidly than the lipid-soluble ones. Furthermore, higher rates of reduction were observed for those dyes containing electron-withdrawing groups on the aromatic rings.
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| http://dx.doi.org/10.1002/jps.2600730206 | DOI Listing |
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