A case of familial oligodendroglioma, occurring in a mother and her daughter, is presented.
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| http://dx.doi.org/10.3171/jns.1984.60.4.0848 | DOI Listing |
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Prognostic and clinical significance of contrast enhancement in WHO grade 2 oligodendrogliomas.
J Neurooncol
January 2025
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.
Purpose: To investigate the prognostic significance of contrast enhancement (CE) in grade 2 oligodendroglioma (ODG) and explore its clinical implications.
Methods: Patients diagnosed with isocitrate dehydrogenase (IDH)-mutant, 1p/19q co-deleted ODG between 2009 and 2016 were retrospectively enrolled from a single institution. The presence of CE was identified on preoperative MRIs, and clinical, radiologic, and histopathological data that was extracted.
The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study.
Lancet Oncol
January 2025
Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:
Background: Gliomas are a major cause of cancer-related death among children, adolescents, and young adults (age 0-40 years). Primary mismatch repair deficiency (MMRD) is a pan-cancer mechanism with unique biology and therapeutic opportunities. We aimed to determine the extent and impact of primary MMRD in gliomas among children, adolescents, and young adults.
View Article and Find Full Text PDFGenetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.
Acta Neuropathol
July 2024
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg Building, 15.238, New York, NY, 10029, USA.
Article Synopsis
- Recent classification changes in adult diffuse gliomas focus on molecular features as key diagnostic criteria, particularly for different types of glioblastomas and astrocytomas.
- The 2021 WHO CNS classification introduced additional molecular alterations into tumor grading, but survival outcomes are still varied within established tumor categories, especially for IDH-mutant astrocytomas.
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Enhanced Methodologies for Investigating the Electrophysiological Characteristics of Endogenous Pannexin 1 Intercellular Cell-Cell Channels.
Methods Mol Biol
April 2024
Centro Interdisciplinario de Neurociencias de Valparaíso, Instituto de Neurociencias, Universidad de Valparaíso, Valparaíso, Chile.
Article Synopsis
- * Pannexin1 (Panx1) proteins, related to invertebrate innexins, are expressed widely in vertebrate cells but still need more research to understand their function and effects.
- * This chapter presents improved cell culture and electrophysiology methods for studying Panx1 in human oligodendroglioma cells, aiming to enhance future research on Panx1's role in various cell types and their implications in health and disease.
Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. 2023, , 3726.
Cancers (Basel)
December 2023
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.
It has come to our attention that the previously published manuscript contained an outdated iteration of Table 1 [...
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