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Interrelationships Between Inflammatory Score, Delayed Cerebral Ischemia and Unfavorable Outcome in Patients with aSAH: A Four-Way Decomposition.
J Inflamm Res
December 2024
Department of Neurosurgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.
Background: To identify biomarkers and develop an inflammatory score based on proper integration to improve risk prediction of delayed cerebral ischemia (DCI) and poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). We also further explore the mediation and interaction of DCI within the chain of events using the four-way effect decomposition.
Methods: Machine learning algorithms are used for biomarker selection and constructed the inflammatory score.
Social Determinants of Health and Lifestyle Risk Factors Modulate Genetic Susceptibility for Women's Health Outcomes.
Pac Symp Biocomput
December 2024
Department of Pathology and Laboratory Medicine, University of Pennsylvania Philadelphia, PA 19104, USA.
Women's health conditions are influenced by both genetic and environmental factors. Understanding these factors individually and their interactions is crucial for implementing preventative, personalized medicine. However, since genetics and environmental exposures, particularly social determinants of health (SDoH), are correlated with race and ancestry, risk models without careful consideration of these measures can exacerbate health disparities.
View Article and Find Full Text PDFLong noncoding RNA mediates enzalutamide resistance and transformation in neuroendocrine prostate cancer.
Front Oncol
November 2024
Department of Urology, Anhui No.2 Provincial People's Hospital, HeFei, China.
Prostate cancer is a malignant tumor caused by the malignant proliferation of epithelial cells, which is highly heterogeneous and drug-resistant, and neuroendocrine prostate cancer (NEPC) is an essential cause of drug resistance in its late stage. Elucidating the evolution of NEPC and the resistance process of enzalutamide, a novel antiandrogen, will be of great help in improving the prognosis of patients. As a research hotspot in the field of molecular biology in recent years, the wide range of biological functions of long noncoding RNAs (lncRNAs) has demonstrated their position in the therapeutic process of many diseases, and a large number of studies have revealed their critical roles in tumor progression and drug resistance.
View Article and Find Full Text PDFNavigating specific targets of breast cancer symptoms: An innovative computer-simulated intervention analysis.
Eur J Oncol Nurs
September 2024
School of Nursing, Guangzhou Medical University, Guangzhou, Guangdong Province, China. Electronic address:
Purpose: To pinpoint optimal interventions by dissecting the complex symptom interactions, encompassing both their static and temporal dimensions.
Methods: The study incorporated a cross-sectional survey utilizing the MD Anderson Symptom Inventory. Participants with breast cancer undergoing chemotherapy were recruited from the "Be Resilient to Breast Cancer" from April 2023 to June 2024.
Hsa_circRNA_000166 accelerates breast cancer progression via the regulation of the miR-326/ELK1 and miR-330-5p/ELK1 axes.
Ann Med
December 2024
Department of Breast Surgery, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Purposes: To probe the expression, clinical significance, roles, and molecular mechanisms of circRNA_000166 in breast cancer (BC).
Methods: Clinical tissue samples were gathered from 84 BC patients who underwent surgery at the Affiliated Hospital of Chengde Medical College. Clinical data were obtained from medical records and postoperative follow-up.
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