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Exploration of the Mechanism of Tanre Qing Injection in Treating Acute Respiratory Distress Syndrome through Network Pharmacology, Molecular Docking, and Animal Experiments.
Comb Chem High Throughput Screen
January 2025
Department of Pharmacy, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangsu, China.
Objective: This study aimed to explore the active components and potential mechanism of Tanre Qing Injection (TRQI) in the treatment of Acute Respiratory Distress Syndrome (ARDS) using network pharmacology, molecular docking, and animal experiments.
Methods: The targets of active ingredients were identified using the TCMSP and Swiss Target Prediction databases. The targets associated with ARDS were obtained from the GeneCards database, Mala card database, and Open Targets Platform.
Deprescribing in Older Adults With Type 2 Diabetes: Associations With Patients' Perspectives: The Diabetes and Aging Study.
J Am Geriatr Soc
January 2025
Division of Research, Kaiser Permanente, Pleasanton, California, USA.
Background: Little is known about how patients' preferences, expectations, and beliefs (jointly referred to as perspectives) influence deprescribing. We evaluated the association of patients' self-reported perspectives with subsequent deprescribing of diabetes medications in older adults with type 2 diabetes.
Methods: Longitudinal cohort study of 1629 pharmacologically treated adults ages 65-100 years with type 2 diabetes who received care at Kaiser Permanente of Northern California (KPNC) and participated in the Diabetes Preferences and Self-Care survey (2019).
Telemedicine for diseases between primary care physicians on remote islands and specialists in mainland in Japan: a questionnaire survey.
J Rural Med
January 2025
Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Japan.
Objective: Primary care physicians on remote islands and specialists in mainland are expected to collaborate using telemedicine. This survey aimed to identify diseases for which primary care physicians on remote islands consider telemedicine necessary.
Materials And Methods: A mail survey was conducted at rural public clinics on remote islands.
Unveiling the endocrine connections of NAFLD: evidence from a comprehensive mendelian randomization study.
Biomed Eng Lett
January 2025
Department of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006 China.
Background: NAFLD is gaining recognition as a complex, multifactorial condition with suspected associations with endocrine disorders. This investigation employed MR analysis to explore the potential causality linking NAFLD to a spectrum of endocrine diseases, encompassing T1D, T2D, obesity, graves' disease, and acromegaly.
Methods: Our methodology leveraged a stringent IV selection process, adhering to the STROBE-MR guidelines.
Adenylate cyclase 9 expression level is associated with hormone receptor-positive breast cancer and predicts patient prognosis.
Nagoya J Med Sci
November 2024
Department of Breast and Endocrine Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Adenylate cyclase family members have recently received attention as novel therapeutic targets. However, the significance of adenylate cyclase 9 (ADCY9) in breast cancer has not been elucidated. Here, we evaluated expression in breast cancer (BC) cell lines, and polymerase chain reaction array analysis was performed to determine the correlations between expression levels and 84 tumor-associated genes.
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