Inbred female rats of the NZR/Gd strain were exceptionally susceptible to nitrosomethylurea (NMU) toxicity after intravesical instillations. After only 1.0 mg NMU total given in 10 fractions, 100% of NZR rats developed malignant bladder tumours. Transitional cell carcinomas predominated (56%) when the NMU dose interval was 2 weeks, and most tumours were squamous carcinomas (57%) with a 1-week interval.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0304-3835(84)90118-6 | DOI Listing |
Publication Analysis
Top Keywords
unusually high
4
high susceptibility
4
susceptibility nzr/gd
4
nzr/gd rats
4
rats bladder
4
bladder cancer
4
cancer induction
4
induction low
4
low doses
4
doses nitrosomethylurea
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!