Herpes simplex infection can appear in a wide variety of clinical presentations. The primary herpes infection can be recognized as grouped vesicles on an erythematous base which may ulcerate. Laboratory confirmation can be made by a rapid Tzanck smear or culture. When used appropriately, acyclovir is effective in treating herpes infection. The drug is available in topical and intravenous forms, and an oral form is being investigated. Acyclovir-resistant viruses have already appeared.
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