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Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
World J Gastroenterol
October 2023
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona 60126, Italy.
Intraductal papillary neoplasms of the bile duct (IPNBs) represent a rare variant of biliary tumors characterized by a papillary growth within the bile duct lumen. Since their first description in 2001, several classifications have been proposed, mainly based on histopathological, radiological and clinical features, although no specific guidelines addressing their management have been developed. Bile duct neoplasms generally develop through a multistep process, involving different precursor pathways, ranging from the initial lesion, detectable only microscopically, biliary intraepithelial neoplasia, to the distinctive grades of IPNB until the final stage represented by invasive cholangiocarcinoma.
View Article and Find Full Text PDFIntraductal papillary neoplasm of the bile duct: review of updated clinicopathological and imaging characteristics.
Br J Surg
August 2023
Department of Surgery and Cancer Research Institute, Seoul National University Hospital, Seoul, Korea.
Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a relatively rare disease and is known as one of the premalignant lesions in the biliary tract. The concept of IPNB has changed through numerous studies and is still evolving. As a lesser studied clinical entity compared with its pancreatic counterpart, intraductal papillary mucinous neoplasm, IPNB has been described in many similar terms, including biliary papillomatosis, biliary intraductal papillary-mucinous neoplasm, and papillary cholangiocarcinoma.
View Article and Find Full Text PDFWe report the case of a 78-year-old woman with dyspepsia for several years and a history of cholecystectomy, informed by pathology as calculous cholecystopathy, where CT revealed a left-sided intrahepatic bile duct dilation. Cholangio-MRI confirmed a size increase in the distal intrahepatic bile duct on the left side, with T2-hyperintense contents with scarce contrast enhancement, which resulted in the observed dilation. .
View Article and Find Full Text PDFClinical characteristics of intrahepatic biliary papilloma: A case report.
World J Clin Cases
May 2021
Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun 130012, Jilin Province, China.
Background: Intrahepatic bile duct papilloma (IPNB) is a rare benign tumour from the bile duct epithelium and has a high malignant transformation rate. Early radical resection can obviously improve the prognosis of patients, but it is difficult to be sure of the diagnosis of IPNB before operating.
Case Summary: This study included 28 patients with intraductal papilloma admitted to the First Hospital of Jilin University from January 2010 to November 2020 and recorded their clinical manifestations, imaging features, complications and prognosis.
Intraductal Papillary Neoplasm of the Bile Duct: A Rare Case of Intrahepatic Space-Occupying Lesion.
Cureus
February 2021
Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.
Intraductal papillary neoplasm of the bile duct (IPNB) is a rare tumor and is considered one of the precursor lesions for cholangiocarcinoma. Though relatively common in the far east countries, it is uncommon in the Indian population. A 67-year-old gentleman presented with vague upper abdominal pain with no history of fever, jaundice, melena, or hematemesis.
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