[Clinical course and morphological characteristics of different types of seminoma].

A comparative analysis of morphological peculiarities and clinical course of seminoma makes the case for distinguishing three types of the tumor. Prognosis in cases of typical seminoma depends on the level of differentiation of tumor cell elements and stage of tumor. Alkylating drugs and radiotherapy should be a method of choice in treatment of patients with typical seminoma. High orchofuniculectomy may be sufficient at the initial stages of spermatocytic seminoma due to its favorable clinical course determined by a high level of specific differentiation of tumor cells. Electron microscopic analysis of anaplastic seminoma showed cells with signs of differentiation towards trophoblast (chorionepithelioma elements) and embryonal entoderm (yolk sac tumor) characterized by a relatively higher malignancy. These data account for the tendency of anaplastic seminoma to rapidly disseminate and suggest application of adjuvant chemotherapy and lymphadenectomy.