AI Article Synopsis
- The structure of globomycin, a new cyclic peptide antibiotic, was established using mass, PMR, and CMR spectra along with chemical degradation methods.
- It is composed of several amino acids: L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine, and 3-hydroxy-2-methylnonaic acid.
- Notably, L-allo-threonine, L-allo-isoleucine, and 3-hydroxy-2-methylnonaic acid are unique components sourced from natural products, and a new mass analysis technique was developed for analyzing diastereoisomers of allo-th
Article Abstract
The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.
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| http://dx.doi.org/10.7164/antibiotics.31.426 | DOI Listing |
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