Electrophysiological evidence of dual intrahisian pathways has been shown in a patient with diseased His bundle. The main electrocardiographic features, in this case were: 1). 1:1 A-V conduction with alternating short and long PR intervals; 2). unexpected A-V Wenckebach sequences; and 3). unexpected interruption of Wenckebach sequences by early captures of the ventricles with short and fixed PR intervals. These features were due to the following causes: 1). different E.P. properties of the two pathways producing a shift of conduction from a fast conducting pathway (FCP) to a slow conducting pathway (SCP); 2). a concealed reentry from the SCP into the FCP; and 3). a phase of "unexpected conduction" in the FCP.
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http://dx.doi.org/10.1016/s0022-0736(84)80031-x | DOI Listing |
J Interv Card Electrophysiol
December 2024
Arrhythmia Department, Teknon Heart Institute, Teknon Medical Center, Barcelona, Spain.
Background: Cardioneuroablation (CNA) treats reflex syncope by ablating ganglionated plexi (GPs) either confined to the right (RA) or left atrium (LA), or accessible from both. We assessed whether GP ablation in one atrium affects parasympathetic modulation in the other and how ablation sequence (RA then LA, or vice-versa) impacts efficacy.
Methods: Two propensity-matched groups of patients with reflex syncope or functional bradycardia were analyzed.
J Med Humanit
September 2024
Yale School of Medicine, Child Study Center, New Haven, CT, USA.
Despite the ubiquity of healthcare simulation and the humanities in medical education, the two domains of learning remain unintegrated. The stories suffused within healthcare simulation have thus remained unshaped by the developments of narrative medicine and the health humanities. Healthcare simulation, in turn, has yet to utilize concepts like co-construction and narrative competence to enrich learners' understanding of patient experience alongside their clinical competencies.
View Article and Find Full Text PDFFront Cardiovasc Med
April 2023
Department of Medicine, Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA, United States.
Background And Significance: The specialized conduction system (SCS) of the heart was extensively studied to understand the synchronization of atrial and ventricular contractions, the large atrial to His bundle (A-H) delay through the atrioventricular node (AVN), and delays between Purkinje (P) and ventricular (V) depolarization at distinct junctions (J), PVJs. Here, we use optical mapping of perfused rabbit hearts to revisit the mechanism that explains A-H delay and the role of a passive electrotonic step-delay at the boundary between atria and the AVN. We further visualize how the P anatomy controls papillary activation and valve closure before ventricular activation.
View Article and Find Full Text PDFJ Electrocardiol
May 2023
Department of Cardiology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, the Netherlands; Hartkliniek Maastricht, Victor de Stuersstraat 15, 6217 KP Maastricht, the Netherlands.
We present the use of CineECG in visualizing abnormal ventricular activation in a case of a complex conduction disorder. CineECG combines the standard 12‑lead surface ECG with a 3D anatomical model of the heart. It projects the location and direction of the average ventricular activation and recovery on the heart model over time.
View Article and Find Full Text PDFCarcinogenesis
April 2021
Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction.
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