Neurological and EMG studies were performed on 17 patients with peripheral facial palsy in order to investigate the possibility of reinnervation of the palsied mimic muscles close to the middle facial line by outgrown fibres from the contralateral intact facial nerve. The patients were aged between 10 and 77 years (middle age 38 years) with duration of the facial palsy from 2 month to 30 years. In eight patients there were data about double reinnervation - both by the ipsilateral lesioned nerve and by the contralateral intact facial nerve. In contrast to the statement of other authors that the age of the patients and the duration of the disease, its severity or the way of occurrence of facial palsy--acute or chronic, are of importance to the development of contralateral reinnervation, our data do not suggest such a role for these factors.
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http://dx.doi.org/10.1055/s-2007-1001997 | DOI Listing |
Plast Reconstr Surg
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Division of Plastic Surgery, Mayo Clinic; Rochester, MN.
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Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts.
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Nursing Department Communicable Diseases Center, Hammad Medical Corporation, Doha 3050, Qatar.
Acrodysostosis (ADO) is a rare form of peripheral dysostosis characterized by skeletal malformations, growth delays, short stature, and distinctive facial features caused by in part by underdeveloped (hypoplasia) of facial bones. Skeletal dysplasia is specific and includes disproportional short stature with short extremities and brachydactyly, multiple cone-shaped epiphyses, scoliosis or kyphosis with spinal stenosis, and advanced bone maturation. Herein, we are highlighting a case that presented with clinical features such as brachydactyly, delayed milestone, growth delay, muscle weakness and nasal hypoplasia.
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January 2025
Department of Microbiology and Immunology, Medical University of South Carolina; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina; Hollings Cancer Center, Medical University of South Carolina;
Chimeric antigen receptor (CAR) T-cell therapy has reshaped the face of cancer treatment, leading to record remission rates in previously incurable hematological cancers. These successes have spurred interest in adapting the CAR platform to a small yet pivotal subset of CD4 T cells primarily responsible for regulating and inhibiting the immune response, regulatory T cells (Tregs). The ability to redirect Tregs' immunosuppressive activity to any extracellular target has enormous implications for creating cell therapies for autoimmune disease, organ transplant rejection, and graft-versus-host disease.
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December 2024
Department of Obstetrics and Gynecology, Rizhao People's Hospital, Rizhao, Shandong, China.
Prenatal diagnosis is a crucial tool in reducing birth defects. Research indicates that whole-exome sequencing (WES) is particularly effective for detecting abnormalities associated with structural ultrasound findings. This study aimed to evaluate the utility of WES in the genetic diagnosis of prenatal ultrasound abnormalities.
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