[Effect of neurotensin and (DTr11)-neurotensin on the secretory function of the pancreas].

In chronic experiments on dogs, administration of neurotensin into cerebral structures (hypothalamus, caudate nucleus) or into the blood flow exerted the same effect: enhancement of the pancreas secretory function, depending on the dosage of the i.v. administration. In contrast, peripheral administration of neurotensin analogue: the DTr11-neurotensin inhibited the pancreas secretory function. Administration of the DTr11-neurotensin into the cerebral structures increased the secretory activity of the pancreas. The hypothalamus and the caudate nucleus seem to have receptors sensitive to neurotensin and DTr11-neurotensin.