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Intrathecal Morphine and Ropivacaine for Quality of Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial.
Drug Des Devel Ther
December 2024
Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, People's Republic of China.
Purpose: Intrathecal morphine is increasingly used for pain management in laparoscopic colorectal surgery. While ropivacaine shows advantages of reduced cardiotoxicity and faster motor recovery compared to bupivacaine, the impact of intrathecal morphine-ropivacaine combination on postoperative recovery quality remains unclear. This study aimed to evaluate this combination's effect on recovery outcomes after laparoscopic colorectal surgery.
View Article and Find Full Text PDFComparative Efficacy of Intrathecal Hyperbaric Levobupivacaine With Fentanyl Versus Hyperbaric Bupivacaine With Fentanyl in Elective Cesarean Section.
Cureus
September 2024
Anesthesiology, Shri B M Patil Medical College Hospital and Research Centre, Bijapur Liberal District Educational (BLDE) University, Vijayapura, IND.
Article Synopsis
- A study was conducted to compare the effects of hyperbaric levobupivacaine versus hyperbaric bupivacaine, both with fentanyl, in women undergoing elective cesarean sections.
- A total of 130 women participated, with findings showing that levobupivacaine resulted in fewer side effects and shorter sensory and motor block durations than bupivacaine.
- Both anesthetics maintained hemodynamic stability, but levobupivacaine provided effective pain relief for a shorter time, suggesting it as a viable option for cesarean procedures.
Simulated bupivacaine pharmacokinetics after labor epidural analgesia followed by transversus abdominis plane block with liposomal bupivacaine for intrapartum cesarean delivery.
J Clin Anesth
December 2024
Columbia University College of Physicians and Surgeons, New York, NY, United States of America. Electronic address:
Study Objective: To simulate bupivacaine pharmacokinetics in scenarios of labor epidural analgesia (LEA) extended for intrapartum cesarean delivery (CD) with epidural or intrathecal boluses, followed by transversus abdominis plane (TAP) block with liposomal bupivacaine (LB) for postcesarean analgesia.
Design: Bupivacaine plasma concentrations were simulated using a 2-compartment distribution model fit to previous study data.
Setting: Virtual pharmacokinetic simulations.
Apelin-13 reverses bupivacaine-induced cardiotoxicity: an experimental study.
Braz J Anesthesiol
May 2024
The First Affiliated Hospital of Wenzhou Medical University, Department of Anesthesiology, Zhejiang Province, China. Electronic address:
Introduction: Cardiac arrest or arrhythmia caused by bupivacaine may be refractory to treatment. Apelin has been reported to directly increase the frequency of spontaneous activation and the propagation of action potentials, ultimately promoting cardiac contractility. This study aimed to investigate the effects of apelin-13 in reversing cardiac suppression induced by bupivacaine in rats.
View Article and Find Full Text PDFIntrathecal ropivacaine versus bupivacaine in a non-obstetric population- A meta-analysis and trial sequential analysis.
Indian J Anaesth
February 2024
Department of Anaesthesia, Liverpool University Hospitals NHS Foundation Trust, England, UK.
Background And Aims: Intrathecal bupivacaine is used for anaesthesia and analgesia but is associated with hypotension. Ropivacaine is an alternative drug that may have fewer cardiotoxic and neurotoxic events. This meta-analysis investigated whether intrathecal ropivacaine is associated with reduced hypotension as compared to bupivacaine.
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