AI Article Synopsis
- Naloxone hydrochloride was effective in restoring normal calcium levels in the extracellular space of injured spinal cords.
- Levels of calcium, which spike after an injury, returned to better than control values within 1.5 hours of treatment.
- Normal ionic activity was achieved after approximately 2 hours and 45 minutes, suggesting naloxone may help mitigate effects from traumatic injuries.
Article Abstract
Naloxone hydrochloride was used to re-establish normal calcium activities in the extracellular space of the injured spinal cord. The micromolar levels of calcium which occur immediately after injury were improved above control values by 1 h 30 min post-injury; normal activities occurred at 2 h 45 min. Such a restitution of ionic levels after injury may contribute to the beneficial effects of naloxone in traumatic injury.
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| http://dx.doi.org/10.1016/0006-8993(84)90753-4 | DOI Listing |
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