Six adolescents with persistent essential hypertension were examined to determine the effect of weight training on their blood pressure and hemodynamics. Five had first completed an endurance training program; one subject trained only by weight lifting. All subjects were reevaluated after 5 +/- 2 months of weight training, and 12 +/- 2 months after cessation of training. Endurance training resulted in an increase in VO2max and decreases in systolic and diastolic blood pressure. After weight training, VO2max had decreased to the level found prior to endurance training, and body weight was significantly increased. Systolic blood pressure after weight training was 17 +/- 4 mm Hg lower than when measured initially (P less than 0.01). Weight training maintained the reduction in diastolic pressure elicited by endurance exercise in those who initially had diastolic hypertension. Cessation of all forms of training resulted in no change in body weight, body fat, or VO2max from the values measured after weight training. Systolic pressure increased significantly with the cessation of training to a value not different from that measured initially. Diastolic pressure also increased after cessation of training, but was still below the initial value. The only significant hemodynamic change found was a reduction in systemic vascular resistance in response to weight training. Weight training in hypertensive adolescents appears to maintain the reductions in blood pressure achieved by endurance training, and may even elicit further reductions in blood pressure.
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Cureus
December 2024
Internal Medicine and Family Medicine, Larkin Community Hospital Palm Springs Campus, Miami, USA.
The purpose of this review is to explore the relationship between weight loss (WL), specifically reductions in body mass index (BMI), and increases in testosterone levels. Obesity and excess body fat are linked to reduced testosterone levels, which can lead to metabolic dysfunctions, reduced libido, and diminished muscle mass. To attain this purpose, this review will summarize current evidence on how weight reduction interventions, including dietary changes, exercise, and bariatric surgery, affect testosterone production in overweight and obese individuals.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Purpose: The incidence of hemodynamic instability associated with dexmedetomidine (DEX) sedation has been reported to exceed 50%, with substantial inter-individual variability in response. Genetic factors have been suggested to contribute significantly to such variation. The aim of this study was to identify the clinical, pharmacokinetic, and genetic factors associated with DEX-induced hemodynamic instability in pediatric anesthesia patients.
View Article and Find Full Text PDFObjective: To assist in the rapid clinical identification of brain tumor types while achieving segmentation detection, this study investigates the feasibility of applying the deep learning YOLOv5s algorithm model to the segmentation of brain tumor magnetic resonance images and optimizes and upgrades it on this basis.
Methods: The research institute utilized two public datasets of meningioma and glioma magnetic resonance imaging from Kaggle. Dataset 1 contains a total of 3,223 images, and Dataset 2 contains 216 images.
Juntendo Iji Zasshi
December 2024
Diabetes mellitus, characterized by high blood glucose due to inadequate insulin action, comprises two main types: type 1, an autoimmune disease, and type 2, marked by insulin resistance. This review provides a comprehensive overview of diabetes management and treatment advancements. Effective diabetes management includes maintaining blood glucose levels within normal ranges and monitoring HbA1c, a marker reflecting average glucose levels over the past few months.
View Article and Find Full Text PDFFront Psychol
January 2025
Sorbonne University, CNRS, INSERM, Institute of Biology Paris Seine, Neurosciences Paris Seine, Paris, France.
Transitive inference, the ability to establish hierarchical relationships between stimuli, is typically tested by training with premise pairs (e.g., A + B-, B + C-, C + D-, D + E-), which establishes a stimulus hierarchy (A > B > C > D > E).
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