Focal rheumatoid inflammation of the dura and leptomeninges was found in an 89-year-old man who was neurologically asymptomatic and had clinically inactive rheumatoid disease. Previous reports of this entity have not stressed that rheumatoid meningitis can be virtually asymptomatic and can develop in persons with apparently quiescent joint disease. The presence of vasculitis of the meningeal or cerebral vessels is associated with symptoms. Intracranial rheumatoid lesions were associated with rheumatoid lesions in other organs, especially the heart and lungs.
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Neurol Sci
January 2025
IRCSS Policlinico San Donato, San Donato Milanese, Italy.
Zhonghua Yan Ke Za Zhi
January 2025
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin300052, China.
Sci Rep
December 2024
Department of Midwifery, School of Nursing and Midwifery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Rational use of steroids is essential in the long term for improving patient safety. Systemic steroids are important in clinical treatment, but if they are misused, they might have negative effects. This study assessed systemic steroid use and its determinants at Debre Berhan University Hakim Gizawu Teaching Hospital (DBUHGTH), Ethiopia.
View Article and Find Full Text PDFAdv Rheumatol
December 2024
Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Objectives: Describe tofacitinib safety from an integrated analysis of randomized controlled trials (RCTs) in patients with ankylosing spondylitis (AS).
Method: Pooled data from Phase 2 (NCT01786668; 04/2013-03/2015)/Phase 3 (NCT03502616; 06/2018-08/2020) RCTs in AS patients were analyzed (3 overlapping cohorts): 16-week placebo-controlled (tofacitinib 5 mg twice daily [BID] [n = 185]; placebo [n = 187]); 48-week only-tofacitinib 5 mg BID (n = 316); 48-week all-tofacitinib (≥ 1 dose of tofacitinib 2, 5, or 10 mg BID; n = 420). Baseline 10-year atherosclerotic cardiovascular disease (ASCVD) risk was determined in patients without history of ASCVD (48-week cohorts).
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