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Immunotherapy on ICU: a narrative review.
Anaesthesia
January 2025
Department of Critical Care, The Royal Marsden Hospital, London, UK.
Background: Patients with cancer account for 15% of all admissions to critical care and so an understanding of the pathophysiology and anticipated complications of specialist treatment is essential for the intensive care clinician. The development of chimeric antigen receptor T-cell therapy for haematological malignancies and immune checkpoint inhibitors for solid organ tumours has led to significant improvements in the prognosis of those patients whose tumours respond. This review is intended to provide the non-specialist with an understanding of the current concepts in pathophysiology, diagnosis and management of complications due to chimeric antigen receptor T-cell therapy and immune checkpoint inhibitors for malignant disease.
View Article and Find Full Text PDFReal-time monitoring and prediction of remote operator fatigue in plateau deep mining based on dynamic Bayesian networks.
Sci Rep
January 2025
Yunnan Diqing Non-Ferrous Metals Co., Ltd, Yunnan, 674400, China.
Fatigue can cause human error, which is the main cause of accidents. In this study, the dynamic fatigue recognition of unmanned electric locomotive operators under high-altitude, cold and low oxygen conditions was studied by combining physiological signals and multi-index information. The characteristic data from the physiological signals (ECG, EMG and EM) of 15 driverless electric locomotive operators were tracked and tested continuously in the field for 2 h, and a dynamic fatigue state evaluation model based on a first-order hidden Markov (HMM) dynamic Bayesian network was established.
View Article and Find Full Text PDFFeasibility study of an experimental social space-oriented rehabilitation concept for people with intellectual and/or multiple disabilities: a study protocol.
BMJ Open
January 2025
Department of Rehabilitation and Sports Medicine, Hannover Medical School, Hannover, Germany.
Introduction: The United Nations underlines the participation in all domains of daily living for people with intellectual and/or multiple disabilities in the Disability Rights Convention, which also includes medical services. In line with this, the German Federal Participation Act has further developed the relevant disability policy at the national level. This also implies access to comprehensive medical care.
View Article and Find Full Text PDFEquity in Basic Medical Education accreditation standards: a scoping review protocol.
BMJ Open
January 2025
Department of Mental Health, Psychiatry & Behavioural Sciences, Peshawar Medical College, Riphah International University, Peshawar, Pakistan.
Introduction: Accreditation in Health Professions Education is a pivotal process to ensure the quality of medical institutions and health professionals. ' is an umbrella term reflecting the principles of justice and support to disadvantaged entities according to their needs. While commonly applied to various domains in medical education, there is potential to determine how ' is considered or discussed while practically implementing accreditation standards for Basic Medical Education (BME) globally.
View Article and Find Full Text PDFFully Integrated MEMS Micropump and Miniaturized Mass Flow Sensor as Basic Components for a Microdosing System.
Micromachines (Basel)
November 2024
Department of Electrical Engineering, TUM School of Computation, Information and Technology, Technical University of Munich, 80333 Munich, Germany.
Despite major advances in the field of actuator technology for microsystems, miniaturized microfluidic actuation systems for mobile devices are still not common in the market. We present a micropump concept and an associated mass flow sensor design, which, in combination, have the potential to form the basis for an integrated microfluidic development platform for microfluidic systems in general and microdosing systems in particular. The micropump combines the use of active valves with an electrostatic drive principle for the pump membrane and the valves, respectively.
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