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Association between epigenome-wide DNA methylation changes and early neurodevelopment in preschool children: Evidence from a former impoverished county in Central China.
Gene
January 2025
Department of Maternal and Child Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China; Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China. Electronic address:
Background: Existing epigenome-wide association study (EWAS) investigating the association between DNA methylation (DNAm) and child neurodevelopment have been predominantly conducted within Western populations, and yielded inconsistent results, leading to a significant gap within non-Western setting, particularly in resource-limited rural areas of Central China.
Objectives: To investigate the association between altered epigenome-wide DNAm and neurodevelopment in preschool children from resource-limited rural areas of Central China.
Methods: This case-control study involved 64 preschoolers.
Modulation of respiration and hypothalamus.
Vitam Horm
January 2025
Clinical Research Center, Murayama Medical Center, Musashimurayama, Japan.
The hypothalamus is the gray matter of the ventral portion of the diencephalon. The hypothalamus is the higher center of the autonomic nervous system and is involved in the regulation of various homeostatic mechanisms. It also modulates respiration by facilitating the respiratory network.
View Article and Find Full Text PDFBirthing Parents' Neural Response to Infant Cry: Moderating Effects of Oxytocin and Perceived Childhood Care.
Soc Cogn Affect Neurosci
January 2025
Department of Psychology, University of Denver.
Unlabelled: Individuals who perceive the caregiving they received from their parents as more caring tend to bond better with their infants and show more sensitive parenting behaviors. Early caregiving experiences are also related to differences in the functions of hormonal systems, including the oxytocinergic system. The current study examined how perceptions of childhood maternal care related to parenting behaviors, oxytocin levels, and neural responses to infant stimuli.
View Article and Find Full Text PDFOxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.
Front Pharmacol
January 2025
Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
Introduction: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders. Recent research indicates that oxytocin (OXY), a neuropeptide typically linked to social bonding and reproductive functions, may influence inflammatory processes. This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.
View Article and Find Full Text PDFImpact of early versus late artificial rupture of membranes during oxytocin induction of labour on the incidence of chorioamnionitis: a randomised controlled trial (ARM trial).
Trials
January 2025
Women's Health, Te Whatu Ora Te Toka Tumai Auckland, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Background: The approach to induction of labour differs internationally, with timing of amniotomy being controversial. Some institutions favour performing artificial rupture of membranes prior to commencement of oxytocin infusion, with the belief that the labour will progress more efficiently. In other institutions, the approach recommended is for oxytocin infusion with intact amniotic membranes until the person has reached the active phase of labour, citing risk of infection with early amniotomy.
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