Investigations of biological rhythms were done in migraine relating the results to certain neurochemical and electroencephalographic studies. The obtained results demonstrated evident individual fluctuations of blood serotonin level in patients with migraine and in control groups. Correlations and connections were demonstrated between the blood serotonin level and EEG pattern and type of migraine. This suggests that the pathomechanism of migrainous headaches may be not homogenous.

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