Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Guanine and isoguanine promote axon regeneration of dorsal root ganglion neurons and survival of retinal ganglion cells after injury.
Exp Neurol
March 2025
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Medical School of Nantong University, Nantong University, Nantong 226001, China. Electronic address:
Neurological injuries usually lead to motor, sensory, or cognitive impairment, which urgently need the development of effective therapeutic strategies. An increasing number of studies have indicated that metabolites can serve as therapeutic drugs for treating diseases or repairing damaged tissues. Among them, purines and their derivatives have shown the neuroprotection effects in the nervous system and garnered significant focus in the field of pharmaceutical development.
View Article and Find Full Text PDFLCN2 deficiency mitigates the neuroinflammatory damage following acute glaucoma.
Theranostics
March 2025
Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China 410008.
Acute high intraocular pressure (IOP) induces retinal ischemia/reperfusion (RI/R) that further initiates neuroinflammatory responses. This event can cause retinal tissue damage and neuronal death, ultimately resulting in irreversible blindness worldwide that lacks effective therapies, validated treatment targets and underlying mechanisms. We sought to explore the potential mechanisms on the causal link between the neuroinflammatory response and neurodegeneration following acute high IOP.
View Article and Find Full Text PDFMULTIMODAL IMAGING IN DEFEROXAMINE-RELATED OCULAR TOXICITY: RAPID DEVELOPMENT DUE TO SUPRATHERPEUTIC DOSING AND PROGRESSION DESPITE DOSE REDUCTION.
Retin Cases Brief Rep
March 2025
Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Purpose: To characterize evolution of deferoxamine-related retinal toxicity in a patient exposed to supratherapeutic doses of deferoxamine and progression despite dose reduction and cessation.
Methods: Observational clinical case Report.
Results: A 59-year-old female with history of beta thalassemia requiring biweekly blood transfusions developed peripheral visual field loss and nyctalopia after taking supratherapeutic dosage of deferoxamine.
Genetic, developmental, and neural changes underlying the evolution of butterfly mate preference.
PLoS Biol
March 2025
Department of Ecology & Evolution, The University of Chicago, Chicago Illinois, United States of America.
Many studies have linked genetic variation to behavior, but few connect to the intervening neural circuits that underlie the arc from sensation to action. Here, we used a combination of genome-wide association (GWA), developmental gene expression, and photoreceptor electrophysiology to investigate the architecture of mate choice behavior in Heliconius cydno butterflies, a clade where males identify preferred mates based on wing color patterns. We first found that the GWA variants most strongly associated with male mate choice were tightly linked to the gene controlling wing color in the K locus, consistent with previous mapping efforts.
View Article and Find Full Text PDFFovealNet: Advancing AI-Driven Gaze Tracking Solutions for Efficient Foveated Rendering in Virtual Reality.
IEEE Trans Vis Comput Graph
March 2025
Leveraging real-time eye tracking, foveated rendering optimizes hardware efficiency and enhances visual quality virtual reality (VR). This approach leverages eye-tracking techniques to determine where the user is looking, allowing the system to render high-resolution graphics only in the foveal region-the small area of the retina where visual acuity is highest, while the peripheral view is rendered at lower resolution. However, modern deep learning-based gaze-tracking solutions often exhibit a long-tail distribution of tracking errors, which can degrade user experience and reduce the benefits of foveated rendering by causing misalignment and decreased visual quality.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!