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Characterization of Newly Isolated Bacteriophages Targeting Carbapenem-Resistant Klebsiella pneumoniae.
J Microbiol
December 2024
Department of Microbiology, School of Medicine, Kyungpook National University, Gukchaebosang-Ro 680, Jung-Gu, Daegu, 41944, Republic of Korea.
Klebsiella pneumoniae, a Gram-negative opportunistic pathogen, is increasingly resistant to carbapenems in clinical settings. This growing problem necessitates the development of alternative antibiotics, with phage therapy being one promising option. In this study, we investigated novel phages targeting carbapenem-resistant Klebsiella pneumoniae (CRKP) and evaluated their lytic capacity against clinical isolates of CRKP.
View Article and Find Full Text PDFGenomic characterisation of an extended-spectrum β-Lactamase-producing Klebsiella pneumoniae isolate assigned to a novel sequence type (6914).
Gut Pathog
November 2024
Department of Microbiology, Babcock University, Ilishan Remo, Ogun State, Nigeria.
Article Synopsis
- The study reports the genome of a novel strain of Klebsiella pneumoniae (Cow102) isolated from raw cow milk in Nigeria, highlighting its potential food safety risks due to multidrug resistance and virulence factors.
- The genome length is over 5.3 million base pairs with various coding sequences, and it shows a new allelic profile (ST6914), indicating ongoing evolution within the species.
- The findings emphasize the need for genomic surveillance in agricultural settings to monitor emerging strains that could pose public health threats.
Characterizing the bacteriophage PKp-V1 as a potential treatment for ESBL-producing hypervirulent K1 ST258 isolated from veterinary specimens.
Vet World
September 2024
Institute of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan.
Background And Aim: The dearth of new antibiotics necessitates alternative approaches for managing infections caused by resistant superbugs. This study aimed to evaluate the lytic potential of the purified bacteriophage PKp-V1 against extended-spectrum β-lactamase (ESBL) harboring hypervirulent (hvKp)-K1 recovered from veterinary specimens.
Materials And Methods: A total of 50 samples were collected from various veterinary specimens to isolate , followed by antimicrobial susceptibility testing and molecular detection of various virulence and ESBL genes.
Harnessing Bacteriophages to Combat Antibiotic-Resistant Infections in Africa: A Comprehensive Review.
Antibiotics (Basel)
August 2024
Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01, Cotonou P.O. Box 2009, Benin.
The conventional treatment of bacterial infections with antibiotics is becoming increasingly ineffective due to the emergence of multidrug-resistant (MDR) pathogens. This literature review explores the potential of bacteriophages as an alternative or adjunctive therapy to antibiotics in combating MDR infections in Africa. This analysis focuses on current research regarding the integration of phage therapy into African healthcare, highlighting its challenges and opportunities.
View Article and Find Full Text PDFInvestigating antibiotic susceptibility and response to bacteriophage and .
Front Microbiol
June 2024
Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Introduction: A total of 94 () isolates were obtained from a hospital in Beijing to evaluate their susceptibility to erythromycin, clarithromycin, doxycycline, and minocycline. As well as the determination of the effectiveness of phages and in -induced lesions mouse model.
Methods: Patients with acne vulgaris (AV) were enrolled from August 2021 to October 2022.
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