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A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis.
Cureus
August 2023
Internal Medicine, Ascension Macomb Oakland, Warren, USA.
While macrocytic anemia is common in vitamin B12 deficiency, rarely, pancytopenia and hemolytic anemia can occur. Homocysteine levels are elevated in severe B12 deficiency, and this is linked to thrombus formation with potentially life-threatening complications. We present a patient with severe vitamin B12 deficiency complicated by hyperhomocysteinemia and obstructive shock from pulmonary embolism.
View Article and Find Full Text PDFAutoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report.
J Med Case Rep
July 2023
Department of Pediatrics, Walter Reed National Military Medical Center, 4494 Palmer Road North, Bethesda, MD, 20814, USA.
Article Synopsis
- Type 1 diabetes mellitus (T1DM) is a lifelong condition that leads to the immune system attacking pancreatic beta cells, resulting in high blood sugar levels and symptoms like frequent urination and weight loss; patients require insulin treatment and are at risk for other autoimmune diseases.
- A 20-year-old female with T1DM presented with gastrointestinal issues and neurological complaints, eventually leading to a diagnosis of autoimmune gastritis after testing revealed low immunoglobulin A levels and elevated gastrin and parietal cell antibodies.
- This case highlights the importance of monitoring and addressing potential autoimmune comorbidities in T1DM patients, as early recognition can improve treatment outcomes and overall health.
Progress in elucidating the relationship between infection and intestinal diseases.
World J Gastroenterol
December 2021
Department of Gastroenterology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba 270-1694, Japan.
() infection causes changes to the intestinal flora, such as small intestinal bacterial overgrowth, and increases gastric acid secretion-stimulating gastrointestinal hormones, mainly gastrin, due to a decrease in gastric acid caused by atrophic gastritis. In addition, the cellular components of travel through the intestinal tract, so the bacterial infection affects the immune system. Therefore, the effects of infection are observed not only in the stomach and the proximal duodenum but also in the small and large intestines.
View Article and Find Full Text PDFChromogranin Serves as Novel Biomarker of Endocrine and Gastric Autoimmunity.
J Clin Endocrinol Metab
August 2020
Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.
Context: The glycoprotein chromogranin A (CgA) is expressed by endocrine and neuroendocrine cells. High levels of serum CgA serve as markers of neuroendocrine tumors (NET), but its role in autoimmunity has not been assessed.
Objective: To investigate CgA utility as a marker of endocrine autoimmunity.
Autoimmune diseases in autoimmune atrophic gastritis.
Acta Biomed
December 2018
Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.
Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus.
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