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Despite insufficient evidence to support direct-to-consumer genetic testing in routine clinical care, cardiovascular clinicians increasingly face questions about its utility and interpretation because individuals can purchase these tests directly from laboratories. A burgeoning marketplace offers an expanding array of testing options. In many cases, direct-to-consumer genetic testing advertises information that could inform one's risk of heritable disease, including insight into having a genetic predisposition to cardiovascular disease or data about gene-drug interactions that could affect response to cardiovascular medications.
View Article and Find Full Text PDFManagement of Popliteal Artery Interposition Graft Infection by Extra-anatomic Bypass.
Vasc Endovascular Surg
March 2025
Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston TX, USA.
ObjectivesInfection of peripheral interposition grafts is a rare but devastating complication following aneurysm repair. Typically, graft infection necessitates explantation and, if possible, revascularization of the limb. However, treatment complexity varies substantially depending on the location and extent of infection.
View Article and Find Full Text PDFAssessing the prognostic value of HALP score in peripheral artery disease: Correlation with lesion severity and long-term mortality.
Vascular
March 2025
Department of Cardiology, School of Medicine, Dicle University, Diyarbakır, Turkey.
IntroductionPeripheral artery disease (PAD) poses a growing clinical challenge due to an aging population, despite advances in treatment methods. Various scoring systems have emerged to predict high-risk patients, including the HALP (hemoglobin, albumin, lymphocyte, and platelet) score, known for predicting prognosis in cancers and stroke. This study assesses the HALP score's relation to lesion severity and long-term mortality in PAD patients.
View Article and Find Full Text PDFNeuropathic Symptoms and Frequency of Chronic Pain in an International Online Sample of Individuals with Sub-Acute and Chronic Stroke.
Healthcare (Basel)
February 2025
Occupational Therapy, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC 3086, Australia.
: Chronic pain is common following a stroke and is associated with increased disability. Yet, little is known about the chronic pain experience in the stroke population. This study aimed to identify and explore the features and neuropathic symptoms of chronic pain in individuals with longstanding stroke.
View Article and Find Full Text PDFRodent Models of Diabetic Neuropathy, Role of Calcium Homeostasis in Pain and KB-R7943 as a Potential Therapeutic.
Int J Mol Sci
February 2025
Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University of Sofia, 1431 Sofia, Bulgaria.
Diabetic neuropathy (DN) is characterized by nerve damage as a consequence of diabetes mellitus. Diabetes causes high blood glucose and triglyceride levels, which destroy the nerve blood vessels over time and trigger DN. Peripheral neuropathy is the most common type of DN, which encompasses a broad range of symptoms.
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