The Authors care about the Isaacs disease; they describe a clinical case and report the result trough carbamazepine and diphenylhydantoin. They think that the hypothesis of nerve suffering, of motor plate suffering does not explain the clinical syndrome. The Authors hypothesize a functional change in the trophic proteins and in the balance excitation-inhibition and neuromodulation. This would explain therefore both the motor syndrome and the vegetative syndrome.
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