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Detection of Deaths Caused by Hyperkalemia.
Biomedicines
January 2025
Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-092 Bydgoszcz, Poland.
Under normal conditions, potassium is predominantly found within cells. The concentration gradient of sodium and potassium ions between intracellular and extracellular spaces enables signal transmission through membrane depolarization. The disruption of this transcellular process leads to elevated potassium ion levels in the extracellular space, and thus in the blood, a condition known as hyperkalemia.
View Article and Find Full Text PDFSoil toxicity, biochemical and histopathological alterations of the cattle egret (Bubulcus ibis) liver at Sharkia province, Egypt, under soil pollution.
Environ Sci Pollut Res Int
January 2025
Department of Zoology, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
The residual concentration of pesticides and heavy metals (arsenic, mercury, selenium, lead, cadmium, and aluminum) was measured in the soil and the cattle egret (Bubulcus ibis) liver from two localities at Sharkia Governorate, Egypt. The pesticide residues have taken the following pattern: chlorpyrifos > metalaxyl > piperonyl butoxide > thiophanate-methyl, in the soil. The residual concentration of pesticides was greater in the soil at Kafr El-Ashraf village (agricultural site) than at El-Qanayat city (garbage site) during the summer season of 2021 compared with the winter season of 2022.
View Article and Find Full Text PDFDehydrothyrsiferol Against Cutaneous Leishmaniasis: Treatment Outcome in a Murine Model.
Mar Drugs
December 2024
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna (ULL), Avenida Astrofísico Francisco Sánchez s/n, 38206 La Laguna, Spain.
One of the most important steps in preclinical drug discovery is to demonstrate the in vivo efficacy of potential leishmanicidal compounds and good characteristics at the level of parasite killing prior to initiating human clinical trials. This paper describes the use of dehydrothyrsiferol (DT), isolated from the red alga , in a pharmaceutical form supported on Sepigel, and the in vivo efficacy against a mouse model of cutaneous leishmaniasis. Studying the ultrastructural effect of DT was also carried out to verify the suspected damage at the cellular level and determine the severity of damages produced in the homeostasis of promastigotes.
View Article and Find Full Text PDFEvaluation of the impact of on the testis of cisplatin-treated albino rats: Biochemical, histopathological, and ultrastructural study.
Histol Histopathol
December 2024
Department of Evaluation of Natural Resources, Environmental Studies and Research Institute, University of Sadat City, Egypt.
Cisplatin is an antineoplastic drug that exhibits toxicity dependent on dosage and has adverse reproductive effects. (Bitter melon) is a natural vegetable plant; its active ingredients possess antioxidant, apoptotic, antiproliferative, hypoglycemic, and other therapeutic properties. This study evaluates the effect of the administration of bitter melon extract, cisplatin, and cisplatin/bitter melon cotreatment on liver and kidney functions, serum and testicular oxidative status, testis histology, and sperm parameters.
View Article and Find Full Text PDFEffect of Food Deprivation on Plasma Cortisol, Carbohydrate Metabolism, and Histomorphology in Clarias batrachus.
Cell Biochem Biophys
January 2025
Department of Zoology, Aligarh Muslim University, Aligarh, UP, India.
The nutritional status of fish is essential for its health, experimental studies, and aquaculture practices. The current study investigated the impact of food deprivation on biochemical parameters, histology of skin, gill, and kidney tissues, and ultrastructure of gills in Clarias batrachus. Fish were subjected to food deprivation for 2, 7, and 15 days resulting in (a) significant increase in plasma cortisol levels, (b) no significant changes in plasma osmolality and plasma glucose content, and (c) significant decrease in liver and muscle glycogen contents.
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