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The IL-6 axis in vascular inflammation: effects of IL-6 receptor blockade on vascular lesions from patients with giant-cell arteritis.
Ann Rheum Dis
March 2025
Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic (member of European Reference Network [ERN]-for rare diseases RITA), University of Barcelona, Centre de Recerca biomèdica (CRB)-CELLEX, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:
Objectives: Blocking interleukin (IL)-6-receptor with tocilizumab has been a major advance in the treatment of giant-cell arteritis (GCA), supporting a crucial role of IL-6 receptor signalling. However, nearly half of the patients are not able to maintain glucocorticoid- free remission with tocilizumab. The impact of tocilizumab on vascular lesions of GCA is largely unknown since conflicting results have been obtained by imaging.
View Article and Find Full Text PDFBackground: The pathogenesis of female pelvic floor polypropylene mesh complications is unclear as trials evaluating explanted mesh have not included asymptomatic controls.
Objectives: To compare explanted polypropylene mesh from those with and without mesh complications to determine the pathogenesis of the complications.
Methods: Between August 2019 and July 2020 66 participants attending Wesley and Royal Brisbane and Women's Hospital Urogynecology department with mesh complications and 15 undergoing repeat prolapse and/or continence surgery after prior polypropylene mesh implantation were included.
Giant Capacitive Energy-Storage in BaTiO-Based Fine-Grained Relaxors via Local Polarization Enhancement.
Adv Mater
March 2025
Beijing Advanced Innovation Center for Materials Genome Engineering, Department of Applied Physics, University of Science and Technology Beijing, Beijing, 100083, China.
Pb-free dielectric energy storage capacitors are core components in advanced pulse-power electronic systems and devices. However, the relatively low energy density (W) for the industrial pillar BaTiO (BT)-based capacitors remains a significant obstacle for their cutting-edge applications, due to their low intrinsic polarization and breakdown strength (E). Herein, through chemical composition and local structure design, a giant W of 15.
View Article and Find Full Text PDFSputnik virophage disrupts the transcriptional regulation of its host giant virus.
J Virol
March 2025
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Japan.
Sputnik virophages are small double-stranded DNA (dsDNA) viruses that replicate only inside host amoebae infected with giant dsDNA viruses, mimiviruses. Sputnik infection affects mimivirus replication, but their molecular interaction remains poorly understood. Here, we performed a time-course transcriptome analysis of cells infected with Acanthamoeba polyphaga mimivirus (APMV; hereafter referred to as Sputnik cells) and those infected with both APMV and Sputnik 3 virophage (Sputnik cells).
View Article and Find Full Text PDFDistinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles.
Adv Biol (Weinh)
March 2025
Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension.
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