The clinical fertility of 1077 men with an infertility problem investigated with semen analysis including assessment of spermatozoa motility during the years 1950-52 was studied 20 years later using a questionnaire, replied by 785 (72.9%). Spermatozoa motility was assessed with a subjective method with four degrees--excellent, good, impaired and poor. There were significant correlations between better motility and number of living children (p less than 0.01) and to shortest time--interval to first pregnancy (p less than 0.001). Motility was not correlated to abortions and otherwise pathological pregnancies. With a poor motility there was still a fairly good chance of obtaining living children (32.7%) compared with 58.7% for an excellent motility), and it is therefore concluded, that assessment of spermatozoa motility is only suited for classification of slightly and modestly reduced male fertility, and not for classification of severely impaired fertility.
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http://dx.doi.org/10.1111/j.1439-0272.1983.tb00192.x | DOI Listing |
Biol Reprod
March 2025
Cell Biology Laboratory, Research Institute for Biosciences, Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.
CRISP2 is enriched in the male reproductive system of mammals and plays roles in spermatogenesis, sperm motility, and fertilization. Although extensively investigated in rodents and boars, human CRISP2 (hCRISP2) remains poorly studied, particularly concerning its localization in testicular and epididymal tissues and its molecular features. In this study, we used immunofluorescence to determine the localization of hCRISP2 in testis, epididymis, and ejaculated sperm.
View Article and Find Full Text PDFFront Vet Sci
February 2025
Key Laboratory for Animal Science of National Ethnic Affairs Commission, Southwest Minzu University, Chengdu, China.
Introduction: Semen cryopreservation is a crucial method for preserving genetic resources and accelerating the breeding process in domestic animals. However, the frozen-thawed process often leads to physical and chemical damage in semen, resulting in oxidative stress that diminishes sperm vitality and fertilization potential. This study aimed to explore the effects of docosahexaenoic acid (DHA) on the quality of frozen-thawed yak semen.
View Article and Find Full Text PDFHum Reprod
March 2025
Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Study Question: Do the main psychoactive phytocannabinoid delta-9-tetrahydrocannabinol (THC) and its non-psychoactive analog cannabidiol (CBD) affect human sperm function?
Summary Answer: THC and CBD affect the sperm-specific Ca2+ channel CatSper, suppress activation of the channel by progesterone (P4) and prostaglandin E1 (PGE1), and THC also alters human sperm function in vitro.
What Is Known Already: Marijuana (Cannabis sativa) is one of the most commonly used recreational drugs worldwide. Although the effects of phytocannabinoids on semen parameters have been studied, there is no evidence of a direct impact of THC and CBD on human sperm.
Int J Mol Sci
February 2025
Department of Biology, Miami University, Oxford, OH 45056, USA.
Utilizing high-resolution microscopy in conjunction with a new antibody highly specific for rat alpha4 Na,K-ATPase, we describe changes in alpha4 expression during spermatogenesis and in sperm incubated under capacitating and noncapacitating conditions. Immunohistochemical analyses showed alpha4 expression at low levels in spermatogonia and in pachytene spermatocytes. Alpha4 then becomes highly expressed on round spermatids and the midpiece of elongated spermatozoa within the seminiferous tubules.
View Article and Find Full Text PDFAnimals (Basel)
March 2025
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.
Hu and Wugu × Hu rams underwent scrotal insulation to simulate mild heat stress, resulting in a 3.0 ± 0.1 °C increase in scrotal surface temperature.
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