On the basis of research and results obtained in recent years that the removing of the spleen increases an aptitude to the infection, the authors have carried out in 1981-1982 four autotransplantations of the spleen; they did it in polytraumatised patients with an extensive rupture of the spleen, where, because of the safe haemostasis, only a splenectomy should have to be performed. By a new technique, removed ruptured spleen is prepared with special procedure, and it is transplanted into the omentum majus of the same patient. There were no complications, although it is concerned of a few patients and a short postoperative follow-up. Three to four months after surgery, the Howwel-Jolly bodies became normal as well as vacuolated erythrocytes and immunophoresis, so that it corresponds to the normal, in-situ, spleen activity; it means that it is to expect a sufficient protection against an infection.
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Biomed Eng Online
January 2025
Department of Cardiovascular Surgery, Division of Cardiovascular Medicine, The Sixth Medical Center, Chinese PLA General Hospital, No.6 of Fucheng Road, Haidian District, Beijing, 100853, China.
Objective: This study aims to investigate the monthly variation patterns of bioelectrical impedance (BEI) along 24 meridian pathways in healthy individuals.
Methods: A cohort of 684 healthy middle-aged participants from North China was enrolled between July 1, 2017, and September 5, 2020. BEI measurements were consistently recorded along the 24 meridian pathways over the study period.
Commun Biol
January 2025
Cardio-Thoracic Translational Medicine (CTTM) Lab, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Recent developments in mass spectrometry-based proteomics have established it as a robust tool for system-wide analyses essential for pathophysiological research. While post-mortem samples are a critical source for these studies, our understanding of how body decomposition influences the proteome remains limited. Here, we have revisited published data and conducted a clinically relevant time-course experiment in mice, revealing organ-specific proteome regulation after death, with only a fraction of these changes linked to protein autolysis.
View Article and Find Full Text PDFBrain Behav Immun
January 2025
Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, Heilongjiang, PR China; The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin 150081, Heilongjiang, PR China. Electronic address:
It has been reported that the nervous system can regulate immune reactions through various mechanisms. However, the role of splenic sympathetic nerve activity in the autoimmune reactions during the pathogenesis of experimental autoimmune encephalomyelitis (EAE) remained unclear. Here, we blocked the activity of the splenic sympathetic nerve and found that the number of adaptive immune cells, such as CD4 T cells, CD8 T cells and B cells, were upregulated.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China; Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. Electronic address:
PIK3CA, which encodes protein p110α, is one of the most frequently mutated oncogenes and a promising drug-target for human cancer. Previously, we demonstrate that p85β is released from PI3K complex which contain PIK3CA helical domain mutations and translocates into nucleus to regulate tri-methylation of H3K27, thereby promoting tumorigenicity. Here, we identify DIRAS2 and SOWAHB as target genes of nuclear p85β in PIK3CA-helical-domain-mutant tumors.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Department of Critical Care Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266000 Shandong, China. Electronic address:
Esmolol has been demonstrated to mitigate inflammation damage and T lymphocyte apoptosis in septic cardiomyopathy. It has been established that the activation of α7 nicotinic acetylcholine receptor (nAChR) by cluster of differentiation 4(CD4) T lymphocytes expressing choline acetyltransferase (ChAT) can prevent excessive inflammation and reduce splenocyte apoptosis in septic cardiomyopathy. Given the similar anti-inflammatory effects, we hypothesized that esmolol might be associated with α7 nAChR and thereby exert its cardioprotective functions.
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