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Cell surface protein-protein interaction profiling for biological network analysis and novel target discovery.
Life Med
August 2024
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
The secretome is composed of cell surface membrane proteins and extracellular secreted proteins that are synthesized via secretory machinery, accounting for approximately one-third of human protein-encoding genes and playing central roles in cellular communication with the external environment. Secretome protein-protein interactions (SPPIs) mediate cell proliferation, apoptosis, and differentiation, as well as stimulus- or cell-specific responses that regulate a diverse range of biological processes. Aberrant SPPIs are associated with diseases including cancer, immune disorders, and illness caused by infectious pathogens.
View Article and Find Full Text PDFIntegrating Metal-Organic Framework Hybrid into Nucleic Acid-Based Hydrogel for Highly Selective Recognition and Sensitive Detection of Sarafloxacin.
Anal Chem
January 2025
State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control of Jiangsu Province, Jiangnan University, Wuxi 214122, China.
Metal-organic framework-based hybrids (MOFzyme) have promising applications in colorimetric aptasensors due to their highly efficient and stable catalytic activity. However, their efficient application in biosensors remains a challenging issue due to the limited reaction site and amorphous structure. Herein, we encapsulated catalase inside MOF cavities to prepare an MOFzyme with many functional groups on its surface, and the functional groups were utilized for the subsequent integration of MOFzyme into the hyaluronic acid-DNA hydrogel.
View Article and Find Full Text PDFReadiness for Perception and Action: Towards a More Mechanistic Understanding of Phasic Alertness.
J Cogn
January 2025
Neuro-Cognitive Psychology, Department of Psychology, Bielefeld University, Bielefeld, Germany.
Human survival requires prompt perception and action to address relevant events in the environment. For this, the brain has evolved a system that uses warning stimuli to elicit phasic alertness, a state readying the brain for upcoming perception and action. Although a wealth of empirical evidence revealed how phasic alertness improves a wide range of perceptual and cognitive processing, it is still unclear by what cognitive mechanisms this is achieved.
View Article and Find Full Text PDFUltra high density imaging arrays in diffuse optical tomography for human brain mapping improve image quality and decoding performance.
Sci Rep
January 2025
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4515 McKinley Ave., St. Louis, MO, 63110, USA.
Functional magnetic resonance imaging (fMRI) has dramatically advanced non-invasive human brain mapping and decoding. Functional near-infrared spectroscopy (fNIRS) and high-density diffuse optical tomography (HD-DOT) non-invasively measure blood oxygen fluctuations related to brain activity, like fMRI, at the brain surface, using more-lightweight equipment that circumvents ergonomic and logistical limitations of fMRI. HD-DOT grids have smaller inter-optode spacing (~ 13 mm) than sparse fNIRS (~ 30 mm) and therefore provide higher image quality, with spatial resolution ~ 1/2 that of fMRI, when using the several source-detector distances (13-40 mm) afforded by the HD-DOT grid.
View Article and Find Full Text PDFBenefits of spaced learning are predicted by the re-encoding of past experience in ventromedial prefrontal cortex.
Cell Rep
January 2025
Department of Psychology, University of Oregon, Eugene, OR, USA.
More than a century of research shows that spaced learning improves long-term memory. However, there remains debate concerning why that is. A major limitation to resolving theoretical debates is the lack of evidence for how neural representations change as a function of spacing.
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