Morphine antagonizes the twitches evoked by administration of PGE2 on spontaneous contractile activity in the isolated uterus of the rat. This action is dose-dependent. Concentrations as low as 2.6 nM completely abolished contractile activity of PGE2 added to the bath at a concentration of 0.5 ng ml-1. In contrast to morphine, pethidine partially antagonized the stimulatory action of PGE2 at much higher concentrations.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
morphine pethidine
8
isolated uterus
8
uterus rat
8
contractile activity
8
antagonism morphine
4
pethidine contractile
4
contractile effects
4
pge2
4
effects pge2
4
pge2 isolated
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!