The isolation and characterization of many of the components of the avoparcin complex are described. A number of mild degradations products from this complex are similarly treated. Conditions for the analytical and preparative HPLC resolution of these materials are outlined.

Download full-text PDF

Source
http://dx.doi.org/10.7164/antibiotics.36.1671DOI Listing

Publication Analysis

Top Keywords

avoparcin complex
8
components degradation
4
degradation compounds
4
compounds avoparcin
4
complex isolation
4
isolation characterization
4
characterization components
4
components avoparcin
4
complex described
4
described number
4

Similar Publications

Article Synopsis
  • Antimicrobial resistance (AMR) can develop unpredictably, as seen with avoparcin usage in farming that led to vancomycin resistance, highlighting past mistakes in antibiotic use.
  • In the EU, there is increasing use of the antibiotic monensin (MON) in livestock, though studies suggest it may not lead to cross-resistance with human antibiotics, some research indicates otherwise.
  • It's crucial to assess if the economic gains from MON's use outweigh environmental impacts and the risk of promoting AMR, emphasizing the need for good animal husbandry practices over reliance on antibiotics.
View Article and Find Full Text PDF

The complex dynamics of antimicrobial activity in the human gastrointestinal tract.

Trans Am Clin Climatol Assoc

March 2014

Department of Medicine, RhodeIsland Hospital, 593 Eddy Street, Providence, RI 02906, USA.

The human gastrointestinal tract is a complex environment of mutualistic associations. As bacteria form a major component of fecal content, the natural balance of the colon can be significantly altered by exposure to antimicrobial agents. However, the effects of antimicrobial therapy on fecal content are difficult to predict and can at times be quite surprising.

View Article and Find Full Text PDF

Two-hundred-twenty-nine food samples of animal origin were tested to know the prevalence of vancomycin-resistant enterococci (VRE) after a decade of avoparcin ban as animal growth promoter in Spain. VRE with acquired mechanism of resistance were detected in 9 of these 229 samples (3.9%, obtained from chicken, veal and rabbit), and one VRE per food sample was further characterized.

View Article and Find Full Text PDF

Micellar electrokinetic chromatography (MEKC) was investigated as a technique for the separation and analysis of the following related glycopeptide antibiotics: alpha-avoparcin, beta-avoparcin, ristocetin A, ristocetin B and vancomycin. Sodium dodecyl sulfate (SDS) micelles were employed as the pseudostationary phase in conjunction with borate or CHES buffers at pH 9.2.

View Article and Find Full Text PDF

The conformational stability of vancomycin group antibiotics (i.e., vancomycin and avoparcin) in aqueous solution has been studied.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!