This is a study of 35 cases of delayed union or established fibrous union ("pseudarthrosis") treated by pulsing electromagnetic stimulation. The treatment, applied up to 12 hours per day, can be carried out at home, with clinical and radiological control every 60 days. The average time of healing was 6 months. Consolidation occurred in 88.5% of cases, usually without the production of excessive periosteal callus. The method was particularly useful and effective in infected fractures, failed bone grafts, revascularisation of fragments showing signs of necrosis, and fractures with associated skin lesions.
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Pharmacoecon Open
January 2025
Department of Health Policy and Medical Technology Research Group, LSE Health, London School of Economics and Political Science, London, UK.
Disparities in access to oncology medicines in European Union (EU) member states can impact patient outcomes profoundly, with availability and timely access varying significantly across and within member states. This paper discusses the intersection of the new European Health Technology Assessment Regulation (HTAR), the provisions of the proposed pharmaceutical legislation and their potential impacts on access to oncology medicines across EU member states. The HTAR, seeking to standardise the clinical evaluation of new medicines, has the potential to streamline the evaluation process but also risks oversimplifying diverse national healthcare needs.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria, 65, 34137 Trieste, Italy.
Pathogenic variants in , encoding dynamin-like protein-1 (DRP1), cause a lethal encephalopathy. DRP1 defective function results in altered mitochondrial networks, characterized by elongated/spaghetti-like, highly interconnected mitochondria. We validated in yeast the pathogenicity of a de novo variant identified by whole exome sequencing performed more than 10 years after the patient's death.
View Article and Find Full Text PDFChildren (Basel)
January 2025
Pediatric Orthopedics, Deformity Reconstruction and Foot Surgery, University Hospital Muenster, 48149 Muenster, Germany.
: Legg-Calvé-Perthes disease (LCPD) presents challenges in treatment due to its varied course and unclear etiology. This study aimed to evaluate the efficacy of combining proximal femoral varus osteotomy (PFVO) with a modified trochanteric flip osteotomy to address biomechanical consequences and improve hip abductor muscle strength. : We present a modified approach combining PFVO with a trochanteric flip osteotomy.
View Article and Find Full Text PDFHealthcare (Basel)
January 2025
Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Objective: This study aims to evaluate and identify the main preoperative risk factors affecting the timely discharge of day surgery patients, offering evidence to enhance preoperative assessments and minimize delayed discharge.
Background: With the widespread adoption of day surgery in global healthcare systems, ensuring timely discharge of patients post-surgery has become a critical challenge. Numerous studies have explored various preoperative risk factors influencing delayed discharge.
Ecol Lett
January 2025
UMR CNRS 7058 « Ecologie et Dynamique Des Systèmes Anthropisés » (EDYSAN), Université de Picardie Jules Verne, Amiens Cedex, France.
Previous studies have demonstrated legacy effects of current species distributions to past environmental conditions, but the temporal extent of such time lag dynamics remains unknown. Here, we have developed a non-equilibrium Species Distribution Modelling (SDM) approach quantifying the temporal extent that must be taken into account to capture 95% of the effect that a given time series of past environmental conditions has on the current distribution of a species. We applied this approach on the distribution of 92 European forest birds in response to past trajectories of change in forest cover and climate.
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