From 1976 to 1978, we examined 1723 wild small mammals, representing 15 species, from three animal production farms and their surroundings in the Trebon basin, south Bohemia, in order to detect antibodies against leptospirosis. Antibodies were found against the serovars grippotyphosa, sorex-jalna, sejroe and/or istrica. The serological positivity was higher in wet grassland stands and fields bordering fishponds. The dominant serovar was grippotyphosa against which antibodies were detected in 8 species of exoanthropic and synanthropic mammals. Owing to the wide ecological valence of the main natural reservoir of L. grippotyphosa--Microtus arvalis, this serovar was present even within the confines of the farms. M. arvalis, together with Apodemus sylvaticus, entering the farm buildings in the cold winter months, can introduce the serovar to the stables housing the farm animals.
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Front Cell Infect Microbiol
January 2025
College of Public Health, North China University of Science and Technology, Tangshan, China.
Enterohemorrhagic (EHEC) is a contagious foodborne pathogen that specifically colonizes the human large intestine, which is regulated by different environmental stimuli within the gut. Transcriptional regulation of EHEC virulence and infection has been extensively studied, while the posttranscriptional regulation of these processes by small RNAs (sRNAs) remains not fully understood. Here we present a virulence-regulating pathway in EHEC O157:H7, in which the sRNA EvrS binds to and destabilizes the mRNA of Z2269, a novel transcriptional regulator.
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February 2025
University of Wisconsin-Madison, Department of Medical Physics, Madison, Wisconsin, United States.
Significance: Protoporphyrin IX (PpIX) delayed fluorescence (DF) is inversely related to the oxygen present in tissues and has potential as a novel biomarker for surgical guidance and real-time tissue metabolism assessment. Despite the unique promise of this technique, its successful clinical translation is limited by the low intensity emitted.
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Cancer Biol Ther
December 2025
Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Membrane-associated RING-CH8 (MARCH8) is a member of the recently discovered MARCH family of ubiquitin ligases. MARCH8 has been shown to participate in immune responses. However, the role of MARCH8 in prognosis and immunology in human cancers remains largely unknown.
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January 2025
Department of Learning and Workforce Development, The Netherlands Organisation for Applied Scientific Research, Soesterberg, Netherlands.
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View Article and Find Full Text PDFOrphanet J Rare Dis
January 2025
Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Heinrich- Heine University, Düsseldorf, Germany.
Background: Patients with Gaucher disease (GD) require continual monitoring; however, lack of specific disease biomarkers was a significant challenge in the past. Glucosylsphingosine (lyso-Gb1) has been shown to be a reliable, key, specific, and sensitive biomarker for diagnosis, prognosis, and treatment response in clinical studies of patients with GD. We evaluated the change in lyso-Gb1 concentration over time following enzyme replacement therapy in patients with confirmed GD using real-world data from the Gaucher Outcome Survey disease registry.
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