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Management challenges of a giant retroperitoneal liposarcoma: A case report and review of the literature.
Int J Surg Case Rep
December 2024
Department of Surgery, Mawenzi Regional Referral Hospital, Moshi, Tanzania.
Introduction And Importance: Atypical lipomatous tumor/well differentiated liposarcoma (ATL/WDL) is an intermediate, locally aggressive malignant mesenchymal neoplasm composed either entirely or in part of a mature adipocytic proliferation showing significant variation in cell size and at least focal nuclear atypia in both adipocytes and stromal cells. Symptoms related to these tumors depend on the anatomic site.
Case Presentation: A 61-year-old female presented with a long-standing worsening abdominal distension.
Strategies in Surgical Salvage: Navigating a Chest Wall Sarcoma Emergency.
Cureus
September 2024
Neurological Surgery, Universitetska Mnogoprofilna Bolnitsa za Aktivno Lechenie (UMBAL) Pulmed, Plovdiv, BGR.
Soft tissue sarcomas arising from the chest wall are an extremely rare entity. They are classified as mesenchymal tumors of varying aggression. It is this unpredictable behavior that makes them an unexpected hurdle even for experienced surgeons.
View Article and Find Full Text PDFTargeting MCM2 activates cancer-associated fibroblasts-like phenotype and affects chemo-resistance of liposarcoma cells against doxorubicin.
Anticancer Drugs
November 2024
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Bone and Soft Tissue Tumor, Peking University Cancer Hospital and Institute, Beijing, China.
Article Synopsis
- Liposarcoma is a common type of soft tissue cancer, and previous research showed that the expression of the gene minichromosome maintenance 2 (MCM2) is increased in liposarcoma tissues.
- The study used various laboratory methods, such as PCR, immunohistochemistry, and assays, to analyze how MCM2 affects liposarcoma cells, including their proliferation, migration, and response to treatment with doxorubicin.
- Results indicated that high levels of MCM2 enhance the formation of cancer-associated fibroblasts (CAFs) and contribute to tumor growth, suggesting that targeting MCM2 might be a valuable treatment strategy for liposarcoma.
Giant Cervical Occipital Lipoma: A Case Report.
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June 2024
Department of Surgical Oncology, Mohammed VI University Hospital, Régional Oncologue Center, Oujda, MAR.
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- * A 46-year-old female with a giant lipoma in the occipital region was assessed after it had been present for 17 years without significant issues, aside from a firm, mobile swelling.
- * Imaging techniques showed characteristics of the lipoma, and successful surgical removal resulted in a full recovery, with pathology confirming it was a benign tumor without any signs of cancer.
Giant paratesticular spindle cell lipoma: A rare case report.
Int J Surg Case Rep
August 2024
Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Universitas Airlangga Teaching Hospital, Surabaya, Indonesia. Electronic address:
Introduction: Spindle cell lipoma (SCL) is a rare condition primarily occurring in subcutaneous tissue. Only 4 cases of paratesticular SCL have been reported.
Case Presentation: A 51-year-old man presented with a painless mass in his left testicle that has grown for nine years.
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