[Relation of the frequency of chromosome aberrations in mouse bone marrow cells to the concentration (dose) of benzene administered by various routes].

Experiments on mice were made to study the rate of bone marrow cells with chromosome aberrations after continuous inhalation of benzene for 7 days at the concentrations 13.9, 36.8 and 73.7 mg/m3 and after a 10-fold intragastric administration of benzene at the doses 5,20 and 80 mg/kg, the interval between administrations being 24 hours. The rate of cells with chromosome aberrations increased as the benzene level was raised (upon both administration routes) and was satisfactorily depicted by linear equations. The doses 36.8 and 20 mg/kg appeared the least effective.