The effect of the diameter of the fusion lock on the forced vergence fixation disparity (FD) curve was investigated because of ambiguity in the results of previous investigations. Data gathered from 20 asymptomatic subjects with normal binocularity showed that the fusion lock diameter had no noticeable effect on the shape of the curve. Further investigations using symptomatic subjects showing large FDs or steep forced vergence FD curves showed that fusion lock diameter did have an effect on the curves of these subjects. The results are interpreted for their clinical implications through a control systems model of the accommodation-vergence interaction.
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Sci Rep
November 2024
Tianjin Key Laboratory of Intelligence Computing and Novel Software Technology, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Blockchain after several years of hustle, bustle, precipitation, and sublimation, with the landing application step by step towards maturity and development, gradually spawned the outreach needs of interacting with other applications. At this stage, only the mobility cross-chain interoperability technology is the infrastructure system that can perfectly solve such needs. To achieve a cross-chain system that defines and realizes user-free liquidity interoperability according to the cross-chain environment and cross-chain requirements, this paper designs a convex optimization-based liquidity contract pair cross-chain model.
View Article and Find Full Text PDFTissue Eng Part A
October 2024
Department of Orthopedics, University Medical Centre Utrecht, Utrecht, The Netherlands.
Autologous bone grafts are commonly used to repair defects in skeletal tissue, however, due to their limited supply there is a clinical need for alternatives. Synthetic ceramics present a promising option but currently lack biological activity to stimulate bone regeneration. One potential approach to address this limitation is the incorporation of immunomodulatory agents.
View Article and Find Full Text PDFNat Nanotechnol
December 2024
Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
In patients with glioblastoma (GBM), upregulated midkine (MDK) limits the survival benefits conferred by temozolomide (TMZ). RNA interference (RNAi) and CRISPR-Cas9 gene editing technology are attractive approaches for regulating MDK expression. However, delivering these biologics to GBM tissue is challenging.
View Article and Find Full Text PDFNat Med
July 2024
Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
PLoS One
May 2024
Department of BioMechanical Engineering, Bio-Inspired Technology Group, Faculty of Mechanical Engineering, Delft University of Technology, Delft, Netherlands.
The success rate of spinal fusion surgery is mainly determined by the fixation strength of the spinal bone anchors. This study explores the use of an L-shaped spinal bone anchor that is intended to establish a macro-shape lock with the posterior cortical layer of the vertebral body, thereby increasing the pull-out resistance of the anchor. The performance of this L-shaped anchor was evaluated in lumbar vertebra phantoms (L1-L5) across four distinct perpendicular orientations (lateral, medial, superior, and inferior).
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