Neurophysins, vasopressin and oxytocin are not restricted to the hypothalamo-neuropituitary system but are also found in different brain area in relation with cognitive and emotional function and with cardiovascular regulation. During early aging it seems to exist a decrease of the hypothalamic and brain content of vasopressin. It appears that in some patients, presumably suffering from a deficit of central vasopressinergic function, exogenous vasopressin could improve arousal and/or memory. The exact place of this peptide in the treatment of the early aging cognitive deficit remains however to be defined.
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