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Variation in compressive mechanical properties between subacute and chronic venous thrombosis in a novel unilateral iliac thrombosis model.
Vasc Med
January 2025
Department of Surgery, Section of Vascular Surgery, Conrad Jobst Vascular Laboratories, University of Michigan Health System, Ann Arbor, MI, USA.
Interventional therapies to relieve chronic deep vein thrombosis (DVT) fail through inability to penetrate, cross, and remove the occlusion. Development of suitable tools requires fundamental understanding of chronic DVT mechanical properties and a reliable model for testing. Female farm swine underwent a novel, endovenous generation of long-segment unilateral iliac vein thrombosis.
View Article and Find Full Text PDFCirculating biomarkers associated with pediatric sickle cell disease.
Front Mol Biosci
December 2024
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, United States.
Article Synopsis
- Sickle cell disease (SCD) is a genetic disorder caused by a mutation in the HBB gene, resulting in abnormal hemoglobin S that deforms red blood cells, leading to severe health complications such as pain, anemia, and organ damage.
- The disease is prevalent, especially in sub-Saharan Africa, where over 7.5 million people are affected, often facing underdiagnosis and poor management, particularly in children.
- This study in Ghana aims to identify specific circulating biomarkers in pediatric SCD patients that could help predict disease outcomes and improve patient care by assessing various serum markers associated with inflammation and neuronal injury.
Venom from Spiders Collected in Southeastern and Northeastern Brazilian Regions Cause Hemotoxic Effects on Human Blood Components.
Toxins (Basel)
December 2024
Molecular Toxinology Lab, Research and Development Department, Ezequiel Dias Foundation-FUNED, Belo Horizonte 30510-010, MG, Brazil.
Spiders of the genus represent a public health problem in Brazil due to the severity of the cutaneous and systemic effects that may result from their bite. In the systemic form of loxoscelism, hemolytic anemia, thrombocytopenia, and disseminated intravascular coagulation can occur. Despite the seriousness of accidents, the venom of some species has not yet been properly characterized considering these hemotoxic effects, such as that of , , and .
View Article and Find Full Text PDFObserver reliability in counting erythrocyte ghost cells and impact of short-term storage of canine and feline blood samples.
Vet J
December 2024
Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, Frederiksberg C DK-1870, Denmark.
The presence of erythrocyte ghost cells (EG) in blood smears indicates intravascular haemolysis or in-vitro haemolysis. However, observer reliability in detection of EG has not been documented. Immediate blood smear preparation is advised but may not always be practical.
View Article and Find Full Text PDFThe Protective Impact of Gd-DTPA on Hemolysis in Pulsed Field Ablation for Atrial Fibrillation.
JACC Clin Electrophysiol
December 2024
Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- * The study investigated the effectiveness of gadolinium-diethylenetriamine-penta-acetic acid (Gd-DTPA), a common MRI contrast agent, in preventing PFA-induced hemolysis through both lab (in vitro) and animal (in vivo) experiments.
- * Results showed that Gd-DTPA significantly reduced cell damage and hemolysis when administered before PFA, likely by strengthening red blood cell membranes, suggesting it could help enhance the safety of PFA treatments
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