A comparative analysis of the number of bone marrow cells forming fibroblastic colonies in culture and of the roentgenological characteristics of bone regenerate during different periods of limb elongation was carried out in dogs. The increase in numbers of colony forming cells in the operated bone and decrease of their number in the intact ones were shown to correspond to the period of active osteogenesis. A distinct negative correlation between the number of colony forming cells in humerus and operated bone is considered as an indirect evidence of the migration of these cells from the intact bones. The number of colony forming cells can be used to estimate quantitatively the intensity of osteogenesis upon reparative regeneration under the conditions of limb elongation.
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