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Intralesional bleomycin sclerotherapy for head and neck low-flow vascular malformations - A retrospective single-center experience.

J Craniomaxillofac Surg

January 2025

Neuroradiology Department, ULS São José, Lisbon, Portugal; NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal; Centro Clínico Académico de Lisboa (CCAL), Lisbon, Portugal.

Low-flow vascular malformations (LFVMs) account for over 90% of all vascular malformations, with the highest prevalence in the head and neck region. Intralesional sclerotherapy is the treatment of choice for subcutaneous LFVMs, although there is no consensus on optimal agent selection or dosage. Mild sclerosing agents, such as bleomycin, are commonly used in sensitive anatomical areas, including the head and neck, due to their favorable safety profile, despite slightly lower efficacy.

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Idiopathic megacolon and megarectum are rare clinical conditions characterized by irreversible dilation of the colon and rectum without an identifiable organic cause. The underlying pathophysiology remains poorly understood, though hypotheses suggest abnormalities in the enteric nervous system or smooth muscle dysfunction. These conditions present significant diagnostic and therapeutic challenges, especially in cases refractory to conservative treatment.

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The combination therapy of lenvatinib plus pembrolizumab (LP) is increasingly recognized as an important second-line regimen for advanced or recurrent endometrial cancer (EC). However, the safety and efficacy of conversion surgery with low anterior rectal resection for unresectable EC following LP therapy is unknown. A 37-year-old woman was referred with unresectable EC with pleural fluid, peritoneal dissemination, and ascites.

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Introduction: Current guidelines recommend percutaneous drainage as the first-line approach for the management of symptomatic lymphoceles following renal transplantation, with surgical fenestration reserved for refractory or recurrent cases. This study evaluates the effectiveness and safety of these therapeutic strategies in renal transplant recipients.

Methods: A retrospective analysis of 109 renal transplant recipients with symptomatic lymphoceles treated between 1993 and 2023 at a single public center was conducted.

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Article Synopsis
  • Emphysematous pyelonephritis (EPN) is a severe urinary tract infection that can lead to high mortality rates, particularly in cases with underlying conditions, but it's rarely reported.
  • A 32-year-old pregnant woman with type 2 diabetes experienced worsening symptoms of pyelonephritis, leading to a diagnosis of EPN through imaging techniques.
  • Successful treatment involved antibiotic therapy, emphasizing the importance of early diagnosis and customized treatment approaches to safeguard both maternal and fetal health during pregnancy.
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