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Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model.
Molecules
February 2023
Department of Chemical and Biochemical Engineering, Institute of Oil and Gas Geology, Satbayev University, Almaty 050013, Kazakhstan.
According to the WHO, the secondary form of hematopoietic-depressive status increases the risk of death in people with oncological, infectious, and hormonal diseases. The choice of drugs that stimulate the hematopoietic activity of B-lymphopoiesis is limited. The current leucopoiesis drugs have a number of side effects: thymic preparations stimulate the production of PGE2, which causes chronic inflammation and various autoimmune diseases through the differentiation of T helper 1 (Th1) cells, the proliferation of Th17 cells, and the production of IL-22 from Th22 cells through EP2 and EP4 receptors; cytokine preparations can cause uncontrolled immune reactions and impaired contractility of smooth and cardiac muscles; drugs based on nucleic acids can stimulate the division of all cells, including bacterial and cancerous ones.
View Article and Find Full Text PDFUltrasonographic approach for a foot ganglion after sewing masks in the COVID-19 pandemic: Blessing in disguise.
Work
January 2021
Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.
Background: During the coronavirus disease (COVID-19) pandemic, people volunteered for sewing hand-made face masks. However, sewing-machine operating might be associated with high ergonomic risk and a negative impact on musculoskeletal health.
Objective And Methods: This paper describes an ultrasonographic diagnosis of a foot ganglion - after sewing 300 face masks within two months using a foot-operated sewing machine.
Errors associated with the concentration of epinephrine in endonasal surgery.
Eur Arch Otorhinolaryngol
July 2011
Department of Otolaryngology, University Hospital Ostrava, 17 listopadu Street 1790, 708 52 Ostrava, Czech Republic.
This paper presents two cases of using erroneous concentrations of epinephrine during endonasal surgery. The two patients discussed were part of a larger study aimed at monitoring the absorption of epinephrine upon injection into the nasal mucosa. During this study, we observed major cardiovascular reactions in two consecutive patients--ventricular tachycardia with ventricular extrasystole and a significant rise in systolic and diastolic blood pressure and pulse rate.
View Article and Find Full Text PDFThe epidural postoperative analgesia after a major urological procedures--a comparison of trimecaine and morphine to bupivacaine and fentanyl.
Bratisl Lek Listy
June 2008
Department of Anaesthesiology and Intensive Care, Charles University, Prague, Czech Republic.
Objectives: To compare the analgesic potency and side effects of epidural combination trimecaine with morphine and bupivacaine with fentanyl in postoperative analgesia after a major urological surgery.
Methods: We randomised 150 consecutive patients. In the trimecain/morphine group (n = 75) trimecaine 50 mg with 4 mg morphine was given epidurally in 8 hour intervals.
[The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia].
Eksp Klin Farmakol
November 2003
Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
The results of experiments on cats and dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, exceeds the structural precursors (trimecaine and lidocaine), as well as the reference drugs quinidine and propranolol, in intensity of the antiarrhythmic action upon single administration on the occlusive and reperfusive arrhythmia models. The therapeutic effect of quaternidine in animals with acute myocardial ischemia lasts for about 8 h, which more than 20 times longer as compared to the duration of action of both lidocaine and trimecaine.
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