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Behav Brain Sci
January 2025
Department of Veterans Affairs Medical Center, Coatesville, PA,
Endogenous reward (intrinsic reward at will) is a that is by steps toward any goals which are challenging and/or uncommon enough to prevent its debasement by inflation. A "theory of mental computational processes" should propose what properties let goals grow from appetites for endogenous rewards. Endogenous reward may be the universal selective factor in all modifiable mental processes.
View Article and Find Full Text PDFMini Rev Med Chem
January 2025
Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126, Pisa, Italia.
Luminescent Lanthanide (III) (Ln(III)) bioprobes (LLBs) have been extensively used in the last two decades as intracellular molecular probes in bio-imaging for the efficient revelation of analytes, to signal intracellular events (enzymes/protein activity, antigen-antibody interaction), target specific organelles, and determine parameters of particular biophysical interest, to gain important insights on pathologies or diseases. The choice of using a luminescent Ln(III) coordination compound with respect to a common organic fluorophore is intimately connected to how their photophysical sensitization (antenna effect) can be finely tuned and especially triggered to respond (even quantitatively) to a certain biophysical event, condition or analyte. While there are other reviews focused on how to design chromophoric ligands for an efficient sensitization of Ln(III) ions, both in the visible and NIR region, this review is application-driven: it is a small collection of particularly interesting examples where the LLB's emissive information is acquired by imaging the emission intensity and/or the fluorescence lifetime (fluorescence lifetime imaging microscopy, FLIM).
View Article and Find Full Text PDFCureus
December 2024
Community Medicine, Dhanalakshmi Srinivasan Medical College and Hospital, Siruvachur, IND.
Background The escalating global obesity epidemic requires comprehensive investigations for effective weight management strategies. Understanding the patterns, barriers, and facilitators of dietary interventions is crucial for developing effective weight management protocols. This research aims to assess dietary modification interventions among weight loss subjects in Tamilnadu, South India.
View Article and Find Full Text PDFNanoscale Adv
January 2025
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology Kattankulathur Tamil Nadu 603203 India
Bone remodeling, a continuous process of resorption and formation, is essential for maintaining skeletal integrity and mineral balance. However, in cases of critical bone defects where the natural bone remodeling capacity is insufficient, medical intervention is necessary. Traditional bone grafts have limitations such as donor site morbidity and availability, driving the search for bioengineered scaffold alternatives.
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