The present study compared the effects of scoring norms on adolescent psychiatric inpatient drug users' and nonusers' MMPI profiles. The results indicated that regardless of drug usage or nonusage the application of adolescent norms yielded less pathological profiles than did the use of adult norms. A further finding was that Scale O, Social Introversion, is the only clinical scale from differentiated users' from nonusers' profiles.
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Ann Intern Med
January 2025
Center for Healthcare Delivery Sciences, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (R.J.D., N.K.C., N.H., J.C.L.).
Background: The evidence informing the harms of gabapentin use are at risk of bias from comparing users with nonusers.
Objective: To describe the risk for fall-related outcomes in older adults starting treatment with gabapentin versus duloxetine.
Design: New user, active comparator study using a target trial emulation framework.
J Med Internet Res
January 2025
Center for Health Services Research, Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Germany.
Background: In recent years, health care has undergone a rapid and unprecedented digital transformation. In many fields of specialty care, such as rheumatology, this shift is driven by the growing number of patients and limited resources, leading to increased use of digital health technologies (DHTs) to maintain high-quality clinical care. Previous studies examined user acceptance of individual DHTs in rheumatology, such as telemedicine, video consultations, and mHealth.
View Article and Find Full Text PDFNPP Digit Psychiatry Neurosci
January 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Reinforcement learning studies propose that decision-making is guided by a tradeoff between computationally cheaper model-free (habitual) control and costly model-based (goal-directed) control. Greater model-based control is typically used under highly rewarding conditions to minimize risk and maximize gain. Although prior studies have shown impairments in sensitivity to reward value in individuals with frequent alcohol use, it is unclear how these individuals arbitrate between model-free and model-based control based on the magnitude of reward incentives.
View Article and Find Full Text PDFAddict Behav Rep
June 2025
Institute of Behavioral Science, University of Colorado Boulder, 1440 15th St., Boulder, CO 80309, USA.
This study examines whether adolescent nicotine and cannabis vaping types (i.e., nicotine-only, cannabis-only, and dual use) differ across sociodemographic and school characteristics (e.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
VA San Diego Healthcare System, San Diego, California, USA; Department of Anesthesiology, School of Medicine, University of California San Diego, USA.
Inhaling aerosols from electronic nicotine delivery systems, such as e-cigarettes (e-cigs), may pose health risks beyond those caused by nicotine intake. Exposure to e-cig aerosols can lead to the release of exosomes and metabolites into the bloodstream, potentially affecting mitochondrial physiology across the body, leading to chronic inflammatory diseases. In this study we assessed the effects of e-cig use by young healthy human subjects on the circulating exosome profile and markers of cell stress, and also defined the effects of e-cig user plasma on mitochondrial function in endothelial cells (EA.
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