Dynamics of respiratory symptoms and past respiratory diseases were studied in a cohort of children examined twice. Relative risk of having the same symptom/disease after three years was calculated, producing a ranking of the symptoms, believed to reflect their epidemiological significance. An independent ordering of the symptoms was obtained, based on the relative risk of lower airways illness in a group of children followed-up for two years. In the analysis of lung function dynamics, practical independence of PEFR measurements and respiratory symptoms was confirmed.
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Transpl Infect Dis
January 2025
Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Background: Infections are a common complication among lung transplant recipients (LuTR), particularly in the first year post-transplant, with respiratory tract infections (RTI) being predominant. Syndromic molecular panels have been suggested to reduce morbidity and mortality by providing a diagnosis quickly. However, integrating these panels into clinical practice remains debated.
View Article and Find Full Text PDFInt J Cancer
January 2025
Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Individuals with AIDS and Kaposi sarcoma (AIDS-KS) with pulmonary involvement have high-risk of poor outcomes but diagnosis of pulmonary KS in low-resource settings is difficult. We aimed to discover plasma proteins that distinguish individuals with pulmonary KS from those without pulmonary involvement. SomaScan proteomics screen measured 7288 plasma proteins in 22 cases and 17 controls selected from 181 participants with HIV-1 and cutaneous KS who underwent bronchoscopy.
View Article and Find Full Text PDFClin Transl Allergy
February 2025
1st University Department of Respiratory Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Background: Data on type 2 (T2)-low severe asthma (SA) frequency is scarce, resulting in an undefined unmet therapeutic need in this patient population. Our objective was to assess the frequency and characterize the profile and burden of T2-low SA in Greece.
Methods: PHOLLOW was a cross-sectional study of adult SA patients.
J Paediatr Child Health
January 2025
Department of Respiratory Medicine, Starship Children's Hospital, Auckland, New Zealand.
Background: Surgical management for bronchiectasis is uncommon. This study reviewed the experience of bronchiectasis surgery and subsequent outcomes at a tertiary paediatric centre over a 20 year period.
Methods: Retrospective audit of children aged < 18 years who underwent bronchiectasis surgery at Starship Children's Hospital between 2001 and 2021.
Nephrology (Carlton)
February 2025
Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine, Oita University, Oita, Japan.
A 73-year-old Japanese man with chronic kidney disease had no history of abnormal clotting or bleeding. Six days after receiving his third dose of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (BNT162b2; Pfizer/BioNTech), blood tests showed a marked prolongation of the prothrombin time-international normalised ratio and activated partial thromboplastin time, as well as a decrease in factor V (FV) activity. Three months later, he required dialysis owing to worsening heart and renal failure.
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