The effect of desglycinamide (8-D-arginine) deaminovasopressin (desgly NH2 dDAVP) on learning was studied in rats using the conditioned taste aversion (CTA) paradigm. Desgly NH2 dDAVP (3 micrograms/kg) applied 40 min before presentation of the gustatory CS (0.1 % saccharin) did not affect CTA formation, when the visceral US (0.15 mol/l LiCl, 2 % body weight) was applied after a 1 h delay. With 2 h CS-US delay the same dosage of the peptide caused CTA impairment, manifested by weaker and faster decaying aversion to saccharin. The above effect of the peptide was blocked by post-CS anesthesia (pentobarbital 40 mg/kg). It is suggested that desgly NH2 dDAVP affects learning indirectly, by increased arousal interfering with the persistence of the short-term gustatory traces in the relatively long CS-US interval.
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