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Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from .
Microbiol Spectr
January 2025
Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
The bacterium is able to invade lung epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, it is currently unclear how OMVs from (PA-OMVs) affect lung epithelial cells and their impact on oxidative stress, autophagy, and other physiological activities of lung epithelial cells. In this study, we found that PA-OMVs activated oxidative stress and autophagy in cells.
View Article and Find Full Text PDFCombining Hyperpolarized Xe MR Imaging and Spectroscopy to Non-Invasively Estimate Pulmonary Vascular Resistance.
J Appl Physiol (1985)
January 2025
Medical Physics Graduate Program, Duke University, Durham, North Carolina, United States.
Hyperpolarized Xe MRI/MRS enables quantitative mapping of function in lung airspaces, membrane tissue, and red blood cells (RBCs) within the pulmonary capillaries. The RBC signal also exhibits cardiogenic oscillations that are reduced in pre-capillary pulmonary hypertension (PH). This effect is obscured in patients with concomitant defects in transfer from airspaces to RBCs, which increase RBC oscillation amplitudes.
View Article and Find Full Text PDFFive-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab: A case report.
World J Gastrointest Surg
January 2025
Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Background: Cirrhotic patients with super-giant hepatocellular carcinoma (HCC) and portal vein invasion generally have a poor prognosis. This paper presents a patient with super-giant HCC and portal vein invasion, who underwent hepatectomy followed by a combination of sorafenib and camrelizumab, resulting in complete remission (CR) for 5 years.
Case Summary: A 40-year-old male with compensated hepatitis B-related cirrhosis was diagnosed with HCC, Barcelona Clinic Liver Cancer stage C.
Interstitial lung disease (ILD) can lead to pulmonary hypertension (ILD-PH), worsening prognosis and increasing mortality. Diagnosing ILD-PH is challenging due to the limitations of imaging methods. Right heart catheterization (RHC) is the gold standard for diagnosing PH but is limited to ILD patients considered for lung transplantation.
View Article and Find Full Text PDFInternal migration and its association with childhood asthma in Ecuador: a cross-sectional study.
Colomb Med (Cali)
January 2025
Universidad Internacional del Ecuador UIDE, School of Medicine, Quito, Ecuador Universidad Internacional del Ecuador Universidad Internacional del Ecuador School of Medicine Quito Ecuador.
Background: Differences in asthma prevalence between urban and rural areas have been observed worldwide. Epidemiological studies in middle- and low-income countries suggest that internal migration processes may partly explain these disparities.
Objective: To investigate the association between internal migration and asthma in children living in transitional areas of Ecuador.
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