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Article Synopsis
  • A 71-year-old man experienced fever and joint pain after a recent throat infection, showing signs of group A streptococcal (GAS) infection with high antistreptolysin O (ASO) levels.
  • The case raised questions about whether he had acute rheumatic fever (ARF) or post-streptococcal reactive arthritis (PSReA), as he displayed symptoms of both conditions.
  • The authors highlight the need for careful consideration of ARF in patients with recent streptococcal infections and joint pain to ensure timely treatment and avoid complications.
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Objective: Rheumatoid nephropathy is one of the most severe extra-articular manifestations of rheumatoid arthritis (RA) associated with a very unfavorable prognosis. This study aimed to identify changes in renal function and morphological variations of kidney diseases in RA patients.

Methods: The study enrolled patients (126 patients) between 18 and 55 years of age with a confirmed active RA of more than 12 months.

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Chorea as the only presenting clinical feature of rheumatic fever: a case report.

Ann Med Surg (Lond)

April 2024

Department of Pediatrics, National Academy of Medical Sciences, Kathmandu, Nepal.

Introduction And Importance: Sydenham's chorea (SC), a major neurological manifestation of acute rheumatic fever (ARF), is commonly seen in young children and adolescents. It is characterized by rapid, unpredictable, involuntary, and nonpatterned contractions affecting mostly distal limbs. It can also be associated with clinical or subclinical carditis.

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Clinical Characteristics of Lung Consolidation with Mycoplasma pneumoniae Pneumonia and Risk Factors for Mycoplasma pneumoniae Necrotizing Pneumonia in Children.

Infect Dis Ther

February 2024

Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Longhu Waihuan East Road, Zhengdong New District, Zhengzhou, 450018, Henan, China.

Introduction: Mycoplasma pneumoniae necrotizing pneumonia (MPNP) is an uncommon but increasingly recognized severe complication of pneumonia, and the delayed diagnosis and treatment are prone to pulmonary sequelae. The aim of this study is to explore independent risk factors for MPNP in children with lung consolidation.

Methods: A retrospective observational study was conducted on 118 children with MPNP (MPNP group) and 184 children with lung consolidation of Mycoplasma pneumoniae pneumonia (MPP) (control group) admitted to Children's Hospital Affiliated to Zhengzhou University from June 2018 to August 2023.

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Objectives/background: Narcolepsy type 1 (NT1) is an immune-mediated disorder characterized by excessive daytime sleepiness, cataplexy, low levels of hypocretin-1 in the cerebrospinal fluid, and a strong association with the HLA DQB1*06:02 allele. There is evidence for streptococcal infections as one pathogenic factor that may lead to NT1 as part of a multifactorial pathogenesis. Elevated titers of Antistreptolysin-O antibodies and increased inflammatory activity in response to streptococci antigens have been described in patients with NT1.

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